HEXAHYDROCURCUMIN Chemical Properties

Melting point:

80-82℃

Boiling point:

622.6±55.0 °C(Predicted)

Density 

1.226

Flash point:

218℃

storage temp. 

2-8°C

solubility 

Chloroform (Sparingly), Ethyl Acetate (Slightly), DCM, DMSO

form 

Solid

pka

10.02±0.20(Predicted)

color 

Pale Yellow

BRN 

2486876

Safety Information

WGK Germany 

3

HEXAHYDROCURCUMIN Usage And Synthesis

Description

Hexahydrocurcumin is a natural product and glucuronide metabolite of curcumin that has anti-inflammatory, antioxidant, and anticancer properties. It reduces prostaglandin E₂ (PGE₂) production stimulated by phorbol 12-myristate 13-acetate (PMA; ) by 37% in human colonic epithelial cells when used at a concentration of 20 μM. Hexahydrocurcumin (3.125-25 μM) inhibits overproduction of nitric oxide induced by LPS in RAW 264.7 macrophage cells in a concentration-dependent manner. It does not affect LPS-induced cytokine release but inhibits LPS-induced iNOS and COX-2 upregulation and NF-κB activation when used at a concentration of 50 μM. Hexahydrocurcumin prevents the formation of aberrant crypt foci in a dimethylhydrazine rat model of colon cancer and potentiates the effect of 5-fluorouracil .

Uses

Hexahydrocurcumin is an intermediate in the synthesis of Gingerenone A (G387500) which is an antifungal and antiparasitic diarylheptenone that is isolated from Zingiber officinale (more commonly known as ginger), a medicinal plant that is used to treat inflammation and musculoskeletal disorders.

Definition

ChEBI: Hexahydrocurcumin is a diarylheptanoid.

target

PGE | NOS | COX

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