2,5-Dihydroxy-1,4-dithiane Chemical Properties

Melting point:

130 °C (dec.) (lit.)

Boiling point:

244.73°C (rough estimate)

Density 

1.224 (estimate)

vapor pressure 

0Pa at 25℃

refractive index 

1.5200 (estimate)

FEMA 

3826 | 2,5-DIHYDROXY-1,4-DITHIANE

storage temp. 

2-8°C

solubility 

H₂O: 0.39% at 20 °C

form 

Crystalline Powder

pka

12.04±0.40(Predicted)

color 

White to yellow

PH

4.9 (3.9g/l, H2O)

Odor

at 0.10 % in propylene glycol. sulfury meaty toasted bread broth egg tomato

Odor Type

sulfurous

Water Solubility 

3.9 g/L (20 ºC)

JECFA Number

550

BRN 

104402

InChIKey

YUIOPHXTILULQC-UHFFFAOYSA-N

LogP

-0.276 at 22.8℃ and pH6.3

CAS DataBase Reference

40018-26-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-41-43-52/53-36/37/38

Safety Statements 

26-36/37/39-61-37/39-24-36

RIDADR 

UN2811

WGK Germany 

2

F 

1-8-10-13

HazardClass 

6.1

PackingGroup 

III

HS Code 

29349990

MSDS

• Language:English Provider:4-Dithiane-2,5-diol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,5-Dihydroxy-1,4-dithiane Usage And Synthesis

Chemical Properties

2,5-Dihydroxy-1,4-dithiane has a sulfurous, meaty, toasted bread-like odor

Chemical Properties

white to yellowish crystalline powder

Uses

1,4-Dithiane-2,5-diol is a hydroxylated dithiane derivative with phytogrowth-inhibitory and antibacterial activities.

Uses

1,4-Dithiane-2,5-diol was used in the synthesis of:

• substituted tetrahydrothiophene derivatives
• 2-amino-3-(arylsulfonyl)thiophenes, potential antiviral and antitumor agents

Definition

ChEBI: 1,4-Dithiane-2,5-diol is a member of dithianes.

Aroma threshold values

Aroma characteristics at 0.1% EtoH: sulfurous, grilled meaty, pungent, brothy, eggy, heavy and rich, toasted bread, tomato

Taste threshold values

Taste characteristics at 0.25 to 10 ppm: metallic, meaty savory chicken and beef, sulfurous, egg-yolk-like

Synthesis Reference(s)

Synthetic Communications, 14, p. 483, 1984 DOI: 10.1080/00397918408059569

General Description

1,4-Dithiane-2,5-diol undergoes bifunctional squaramide catalyzed sulfa-Michael/aldol cascade reaction with chalcones to afford trisubstituted tetrahydrothiophenes. It participates in diastereoselective [3+3] cycloaddition with azomethine imines catalyzed by 1,4-diazabicyclo[2.2.2]octane. It is a mercaptoacetaldehyde dimer and an efficient synthon for incorporating a thiol group to in situ generated nitroalkenes.

2,5-Dihydroxy-1,4-dithiane(40018-26-6)Related Product Information

• Solvent Red 43
• Triclosan
• 1,4-Butanediol
• DL-Dithiothreitol
• Chrysin
• Dimethyl disulfide
• 1-Hydroxyethylidene-1,1-diphosphonic acid
• 1,3-Dihydroxyacetone
• Butylated Hydroxytoluene
• Selenium sulfide
• 1,2-Pentanediol
• 3-Diethylaminophenol
• Ethyl 2-hydroxyethyl sulfide
• 4-Dithiane-2,5-diol,2,5-dimethyl-
• 1,4-Dithiane
• 1,2-Ethanedithiol
• 2-(3,4-Dimethoxyphenyl)-N-(3,4-dimethoxyphenethyl)-N-methyl-1,3-dithiane-2-propan-1-amine 1,1,3,3-tetraoxide
• trans-1,2-Dithiane-4,5-diol, Oxidized DTT,trans-1,2-dithiane-4,5-diol,trans-1,2-Dithiane-4,5-diol, Oxidized DTT,rel-(4R*,5R*)-1,2-Dithiane-4,5-diol