Piretanide Chemical Properties

Melting point:

225-227°

Boiling point:

253°C (rough estimate)

Density 

1.3049 (rough estimate)

refractive index 

1.6510 (estimate)

storage temp. 

2-8°C

solubility 

Very slightly soluble in water, sparingly soluble in anhydrous ethanol. It shows polymorphism (5.9).

pka

10.22±0.60(Predicted)

form 

Solid

color 

Pale-yellow platelets from MeOH (aq)

CAS DataBase Reference

55837-27-9(CAS DataBase Reference)

Safety Information

Toxicity

LD50 in rats, mice (mg/kg): 5601, 3672 orally (Merkel)

Piretanide Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Originator

Arelix ,Hoechst, Italy ,1980

Uses

High-ceiling loop diuretic; structurally related to Bumetanide (B689550). Diuretic.

Definition

ChEBI: Piretanide is an aromatic ether.

brand name

Arlix (Hoechst-Roussel).

Therapeutic Function

Diuretic

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Used as a diuretic agent. When heated to decomposition it emits very toxic fumes of SOx an

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