(-)-Denudatin B Chemical Properties

Boiling point:

491.1±45.0 °C(Predicted)

Density 

1.18±0.1 g/cm3(Predicted)

storage temp. 

4°C, away from moisture and light

form 

Oil

color 

Colorless to light yellow

(-)-Denudatin B Usage And Synthesis

Definition

ChEBI: Denudatin B is a member of benzofurans.

Biological Activity

(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels[1]. And (-)-Denudatin B has nonspecific antiplatelet action

References

[1]. Yu SM,et al. Vasorelaxing effect in rat thoracic aorta caused by denudatin B, isolated from the Chinese herb, magnolia fargesii. Eur J Pharmacol. 1990;187(1):39-47. [2]. Teng CM, et al. Inhibition of thrombin- and collagen-induced phosphoinositides breakdown in rabbit platelets by a PAF antagonist--denudatin B, an isomer of kadsurenone. Thromb Res. 1990;59(1):121-130.

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