2-CHLORO-4-PHENYLQUINAZOLINE Chemical Properties

Melting point:

113.0 to 117.0 °C

Boiling point:

347.4±30.0 °C(Predicted)

Density 

1.285±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder to crystal

pka

0.24±0.30(Predicted)

color 

White to Orange to Green

Safety Information

HS Code 

2933998090

2-CHLORO-4-PHENYLQUINAZOLINE Usage And Synthesis

Uses

2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators.

Uses

2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators.

Uses

2-CHLORO-4-PHENYLQUINAZOLINE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ?? C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield).

2-CHLORO-4-PHENYLQUINAZOLINE(29874-83-7)Related Product Information

• 4-Chlorophenylacetone
• CHLOROPHENYLSILANE 97
• 4,4'-DDT
• 2-CHLORO-4-PHENYLQUINAZOLINE
• 2-chloro-4-(4-chlorophenyl)quinazoline
• 2,6-DICHLORO-4-PHENYL-QUINAZOLINE
• 2-CHLORO-6-METHYL-4-PHENYL-QUINAZOLINE
• 6-BROMO-2-CHLORO-4-PHENYLQUINAZOLINE