2-CHLORO-4-PHENYLQUINAZOLINE Chemical Properties

Melting point:

113.0 to 117.0 °C

Boiling point:

347.4±30.0 °C(Predicted)

Density 

1.285±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder to crystal

pka

0.24±0.30(Predicted)

color 

White to Orange to Green

InChI

InChI=1S/C14H9ClN2/c15-14-16-12-9-5-4-8-11(12)13(17-14)10-6-2-1-3-7-10/h1-9H

InChIKey

SFKMVPQJJGJCMI-UHFFFAOYSA-N

SMILES

N1=C2C(C=CC=C2)=C(C2=CC=CC=C2)N=C1Cl

Safety Information

HS Code 

2933998090

2-CHLORO-4-PHENYLQUINAZOLINE Usage And Synthesis

Uses

2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators.

Uses

2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators.

Uses

2-CHLORO-4-PHENYLQUINAZOLINE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ?? C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield).

References

[1] Patent: KR2017/10582, 2017, A. Location in patent: Paragraph 0251-0254
[2] Patent: KR2016/74426, 2016, A. Location in patent: Paragraph 0162; 0163; 0164; 0165
[3] Patent: KR2017/97450, 2017, A. Location in patent: Paragraph 0317-0319; 0337-0339
[4] Patent: WO2012/67425, 2012, A1. Location in patent: Page/Page column 39-40
[5] Patent: WO2012/36482, 2012, A1. Location in patent: Page/Page column 27-28

2-CHLORO-4-PHENYLQUINAZOLINE(29874-83-7)Related Product Information

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