4-FLUORO-2-METHOXYANILINE Chemical Properties

Boiling point:

215℃ (756 Torr)

Density 

1.176±0.06 g/cm3 (20 ºC 760 Torr)

refractive index 

1.5400 to 1.5440

Flash point:

79.5±21.8℃

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

Solid

pka

4.60±0.10(Predicted)

color 

Colorless to Brown

InChI

InChI=1S/C7H8FNO/c1-10-7-4-5(8)2-3-6(7)9/h2-4H,9H2,1H3

InChIKey

BNRRMRUVYDETQC-UHFFFAOYSA-N

SMILES

C1(N)=CC=C(F)C=C1OC

Safety Information

RIDADR 

2810

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

2921420090

4-FLUORO-2-METHOXYANILINE Usage And Synthesis

Physical Form

Yellow to Orange to Brown Solid or liquid

Application

4-Fluoro-2-methoxyaniline is a useful synthetic intermediate. It is used to prepare ortho-substituted phenylureas as 5-Hydroxytryptamine (5-HT3) receptor antagonists. It is also used to synthesize hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain.

Synthesis

Using 4-fluoro-2-o-methoxynitrobenzene as the starting material, the target compound 4-fluoro-2-methoxyaniline was prepared by hydrogenation reduction reaction.

References

[1] Patent: US6352993, 2002, B1. Location in patent: Page column 30
[2] Patent: CN106366072, 2017, A. Location in patent: Paragraph 0062; 0063; 0064; 0090; 0091; 0092
[3] Patent: CN106366022, 2017, A. Location in patent: Paragraph 0051; 0052; 0056
[4] Patent: US2011/130415, 2011, A1. Location in patent: Page/Page column 102
[5] Patent: WO2018/207120, 2018, A1. Location in patent: Page/Page column 11; 12

4-FLUORO-2-METHOXYANILINE(450-91-9)Related Product Information

• 4-FLUORO-2-METHOXYANILINE
• 2-Acetonyloxy-3,4-difluoro nitrobenzene
• Levofloxacin
• Levofloxacin carboxylic acid
• Ipodate Sodium
• Marbofloxacin
• 5-Fluoro-2-nitroanisole
• o-Anisidine
• METHYL 2-(5-FLUORO-2-NITROPHENOXY)ACETATE
• R-(+)-OFLOXACIN
• 5-FLUORO-2-NITROPHENYL 4-(CHLOROMETHYL)BENZOATE
• 5-FLUORO-2-NITROPHENYL 3-METHYLBENZOATE
• 5-FLUORO-2-NITROPHENYL 2-FLUOROBENZOATE
• 5-FLUORO-2-NITROPHENYL 4-NITROBENZOATE
• 5-FLUORO-2-NITROPHENYL 2,6-DIFLUOROBENZOATE
• 5,5I DIFLUORO BAPTA(K+ SALT)
• 5-FLUORO-2-NITROPHENYL 2-CHLOROBENZOATE
• 5-FLUORO-2-NITROPHENYL 2-(2-METHOXYPHENYL)-5-OXOTETRAHYDROFURAN-3-CARBOXYLATE