ISOXANTHOHUMOL Chemical Properties

Melting point:

183 - 187°

Boiling point:

585.8±50.0 °C(Predicted)

Density 

1.245±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

powder

pka

7.90±0.40(Predicted)

color 

Pale Yellow

BRN 

10199264

Safety Information

WGK Germany 

3

ISOXANTHOHUMOL Usage And Synthesis

Description

Isoxanthohumol is a natural, prenylated chalcone isolated from the hop plant, H. lupulus (hops). It has diverse biological activities, including antiproliferative, anti-inflammatory, and antiviral properties. In B16 and A375 melanoma cells, isoxanthohumol inhibits proliferation (IC₅₀s = 22.15 and 22.9 μM in an MTT assay), slows cell division, and induces apoptosis. Isoxanthohumol reversibly inhibits K_v1.3 channels with an EC₅₀ value of 7.8 μM in human Jurkat T cells using patch clamp electrophysiology. It has strong deterrent properties against the peach potato aphid. It has also been used as a marker of beer consumption. Isoxanthohumol is metabolized in the liver and intestine to 8-prenylnaringenin , a potent phytoestrogen.

Uses

Isoxanthohumol is a prenylated flavone isolated from hop. A chromane-like cyclic prenylflavonoids for neurological disorder therapy. Isoxanthohumol is a prenylated flavonoid phytoestrogen which is an apoptosis inducer in mature adipocytes

Definition

ChEBI: Isoxanthohumol is a member of flavanones.

ISOXANTHOHUMOL(521-48-2)Related Product Information

• ISOPIMPINELLIN
• 2-(3-Methoxy-4-hydroxyphenyl)-6-α-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one
• (+/-)-8-PRENYLNARINGENIN
• ISOXANTHOHUMOL(NEW)(PRIMARY STANDARD)
• ISOXANTHOHUMOL(NEW)(P)
• Isoxanthohumol【Helichrysum】