5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE
5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE Basic information
- Product Name:
- 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE
- Synonyms:
-
- 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE
- 5-pregnen-3B-ol-20-one-16A-carbonitrile
- (3S,8S,9S,10R,13S,14S,16R,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile
- (3S,8S,9S,10R,13S,14S,16R,17S)-17-ethanoyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile
- pregnenolone-16α-carbonitrile
- 16α-Cyano-3β-hydroxypregn-5-en-20-one
- U-14975
- 16-alpha)-3-hydroxy-20-oxopregn-5-ene-16-carbonitrile(3-bet
- CAS:
- 1434-54-4
- MF:
- C22H31NO2
- MW:
- 341.49
- Mol File:
- 1434-54-4.mol
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5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE Chemical Properties
- Melting point:
- 225-228 °C(Solv: methanol (67-56-1); benzene (71-43-2))
- Boiling point:
- 508.5±50.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- Flash point:
- 93 °C
- storage temp.
- 2-8°C
- solubility
- Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml
- form
- White to off-white solid.
- pka
- 14.95±0.70(Predicted)
- EPA Substance Registry System
- Pregn-5-ene-16-carbonitrile, 3-hydroxy-20-oxo-, (3.beta.,16.alpha.)- (1434-54-4)
MSDS
- Language:English Provider:SigmaAldrich
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5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE Usage And Synthesis
Uses
Pregnenolone Carbonitrile is a glucocorticoid receptor antagonist that induces the expression of the CYP3A family of steroid hydroxylases and modulates sterol and bile acid biosynthesis in vivo. Pregnenolone Carbonitrile is an an activator of rat pregnane X receptor (PXR).
Definition
ChEBI: Pregnenolone 16alpha-carbonitrile is an aliphatic nitrile. It is functionally related to a pregnenolone.
Biochem/physiol Actions
Pregnenolone-16a-carbonitrile (PCN) is a glucocorticoid receptor antagonist and a PXR (pregnane X receptor) activator.
5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILESupplier
Shanghai Macklin Biochemical Co.,Ltd.
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- 15221275939 15221275939
- shenlinxing@macklin.cn
Sigma-Aldrich
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
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Lynnchem
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- 86-(0)29-85992781 17792393971
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Novachemistry
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- 44-20819178-90 02081917890
- info@novachemistry.com
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5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE(1434-54-4)Related Product Information
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- 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE