4-chloro-17a-methyl-androst-1,4-diene-3,17b-diol Chemical Properties

Boiling point:

465.5±45.0 °C(Predicted)

Density 

1.20±0.1 g/cm3(Predicted)

pka

12.46±0.70(Predicted)

InChI

InChI=1/C20H29ClO2/c1-18-9-8-16(22)17(21)15(18)5-4-12-13(18)6-10-19(2)14(12)7-11-20(19,3)23/h8-9,12-14,16,22-23H,4-7,10-11H2,1-3H3/t12-,13+,14+,16?,18-,19+,20+/s3

InChIKey

ZHWBNJVZZYSUJZ-HXKLKIPJNA-N

SMILES

C1(O)C(Cl)=C2[C@](C)(C=C1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@](C)(O)CC3)CC2 |&1:5,9,11,13,15,19,r|

4-chloro-17a-methyl-androst-1,4-diene-3,17b-diol Usage And Synthesis

History

As a synthetic, orally active anabolic-androgenic steroid (AAS) and a 17α-alkylated derivative of 4-androstenediol, 4-chloro-17a-methyl-androst-1,4-diene-3,17b-diol was never marketed. It was first encountered in 2005 when it was introduced as a dietary supplement and putative prohormone under the name Halodrol-50 by industry veteran, Bruce Kneller while working with the dietary supplement company, Gaspari Nutrition.

Uses

4-chloro-17α-methylandrost-1,4-diene-3β,17β-diol, also known as Chlorodehydromethylandrostenediol (CDMA), is a 17-alpha alkylated steroid that converts to the steroid Oral Turinabol (C365220) after interacting with 3-β-HSD enzyme. Studies suggested the lack of progestational effects of Halodrol m ay be due to the the 4-chloro group, where it restricts the interaction with aromatase enzyme to produce inactive 4-chloro-DHT metabolites, thus producing significantly less androgenic side effects.

Side effects

When taken by mouth: Halodrol-50 (4-chloro-17a-methyl-androst-1,4-diene-3,17b-diol) is possibly unsafe for most people when taken by mouth. Side effects include liver damage, infertility, behavioral changes, hair loss, and others.

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