2,4-Dichlorobenzyl alcohol Chemical Properties

Melting point:

55-58 °C(lit.)

Boiling point:

150 °C (25 mmHg)

Density 

1.2970 (rough estimate)

vapor pressure 

0.154Pa at 25℃

refractive index 

1.5756 (estimate)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

1g/l

pka

13.60±0.10(Predicted)

form 

Solid

color 

White to Off-White

Water Solubility 

Soluble in water, methanol and chloroform.

Merck 

14,3060

BRN 

1448652

InChIKey

DBHODFSFBXJZNY-UHFFFAOYSA-N

LogP

2.8 at 24℃

CAS DataBase Reference

1777-82-8(CAS DataBase Reference)

EPA Substance Registry System

2,4-Dichlorobenzenemethanol (1777-82-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

24/25

WGK Germany 

2

RTECS 

DO0890000

Hazard Note 

Irritant

HS Code 

29062900

Toxicity

mouse,LD50,oral,2300mg/kg (2300mg/kg),Cosmetics and Toiletries. Vol. 95(6), Pg. 59, 1980.

MSDS

• Language:English Provider:2,4-Dichloro-benzenemethanol
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,4-Dichlorobenzyl alcohol Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Uses

An surgical antiseptic.

Uses

2,4-Dichlorobenzyl alcohol is an antiseptic found in commercially available throat lozenges. Also used deactivate Respiratory syncytial virus and SARS-Cov.

Definition

ChEBI: A member of the class of benzyl alcohols that is benzyl alcohol in which the hydrogens at positions 2 and 4 are replaced by chlorines.

General Description

2,4-Dichlorobenzyl alcohol is a constituent of commercially available lozenges for acute sore throat caused by upper respiratory tract infections.

Mechanism of action

In-vitro evidence has demonstrated the virucidal effect of Amylmetacresol (AMC) and 2,4-dichlorobenzyl alcohol (DCBA) on a number of viruses associated with the common cold; a reduction in viral load is believed to have benefits in reducing the symptoms. The local anesthetic action of AMC/DCBA throat lozenges, a combination of the potent channel blocker – AMC and the reduced potency for sodium channel blockade DCBA – attenuate the effects of AMC, possibly as a result of competitive binding, which acts on a sodium channel blocker, and may be effective in relieving symptoms due to inflammation. Therefore, AMC/DCBA throat lozenge is thought to represent a useful option to meet patients' needs and avoid unnecessary prescription of antibiotics[1].

Clinical Use

Amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges have been marketed in many countries worldwide for pain relief in acute sore throat. Amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges have been shown to be safe and efficient in relieving of acute sore throat symptoms, and it produces an immediate symptomatic relief. Local symptomatic pain relief plays an important role in managing acute sore throat[1-2].

Side effects

COMMON SIDE EFFECTS: Difficulty in breathing, Tongue soreness, Hypersensitivity reactions, Swelling of the face, Tongue, Throat and Neck.

References

[1] Ting W Tan. “Effectiveness of amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges in patients with acute sore throat due to upper respiratory tract infection: a systematic review protocol.” JBI database of systematic reviews and implementation reports (2017): 862–872.
[2] Thomas, Michael J. “ACP Journal Club. Amylmetacresol and 2, 4-dichlorobenzyl alcohol lozenges were better than placebo lozenges for relief of acute sore throat.” Annals of Internal Medicine 153 4 (2010): JC2-6.

2,4-Dichlorobenzyl alcohol(1777-82-8)Related Product Information

• 4-Hydroxybenzyl alcohol
• 4-Methoxybenzyl alcohol
• 4,4'-Bis(chloromethyl)-1,1'-biphenyl
• 4-Nitrobenzyl alcohol
• 1,3-Bis(chloromethyl)benzene
• Thionyl chloride
• Dichloroethane
• Triphenylmethanol
• 4,6-Dichloropyrimidine
• Ethyl acetate
• Dichloroacetic acid
• Benzyl alcohol
• 2,3-DICHLOROBENZYL ALCOHOL 99%,2,3-DICHLOROBENZYL ALCOHOL
• Miconazole Impurity
• Isoconazole
• Miconazole IMpurity I
• alpha-(2,4-Dichlorophenyl)-1H-imidazole-1-ethanol
• Miconazole IMpurity H