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DMT-dG(dmf) Phosphoramidite

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DMT-dG(dmf) Phosphoramidite Basic information

Product Name:
DMT-dG(dmf) Phosphoramidite
Synonyms:
  • N4-(DIMETHYLAMINO)METHYLENE)-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE
  • DMT-dG(dmf) amidite
  • N2-(dimethylamino)methylene-deoxyguanosine Phosphoramidite
  • (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-((E)-(dimethylamino)methyleneamino)-6-oxo-1H-purin-9(6H)-yl)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite
  • REF DUPL: DMF-dG-CE-Phophoramidite
  • N4-(Dimethylamino) methylene)-5'-O-(dimethoxytrityl)-2'-deoxyguanosine-3'-N,N-diisopropyl(cyanoethyl) phosphoramidite
  • 2'-Deoxy-N2-DMF-5'-O-DMT-guanosine 3'-CE phosphoramidite
  • DMF-dG-CE Phosphoramidite
CAS:
330628-04-1
MF:
C43H53N8O7P
MW:
824.9
EINECS:
2017-001-1
Product Categories:
  • DNA Amidites
  • Fast Deprotection DNA Amidites
  • Sigma-Proligo
  • Pharmaceutical
  • RNAi
  • Amidite
Mol File:
330628-04-1.mol
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DMT-dG(dmf) Phosphoramidite Chemical Properties

Boiling point:
876.3±75.0 °C(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO : 100 mg/mL (121.23 mM; Need ultrasonic)
pka
3.80±0.20(Predicted)
form 
powder
color 
white to off-white
InChI
InChI=1/C43H53N8O7P/c1-29(2)51(30(3)4)59(56-24-12-23-44)58-36-25-38(50-28-45-39-40(50)47-42(48-41(39)52)46-27-49(5)6)57-37(36)26-55-43(31-13-10-9-11-14-31,32-15-19-34(53-7)20-16-32)33-17-21-35(54-8)22-18-33/h9-11,13-22,27-30,36-38H,12,24-26H2,1-8H3,(H,47,48,52)/b46-27+/t36-,37+,38+,59?/s3
InChIKey
YRQAXTCBMPFGAN-UNHDIWNRSA-N
SMILES
C12N=C(/N=C/N(C)C)NC(=O)C=1N=CN2[C@H]1C[C@@H]([C@@H](COC(C2C=CC=CC=2)(C2C=CC(OC)=CC=2)C2=CC=C(C=C2)OC)O1)OP(OCCC#N)N(C(C)C)C(C)C |&1:15,17,18,r|
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Safety Information

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29349990
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DMT-dG(dmf) Phosphoramidite Usage And Synthesis

Chemical Properties

White or off-white power

Uses

Dmf-dG-CE phosphoramidite is a nucleotide and guanosine (G837895) derivative used in the preparation of synthetic RNA fragments, and other macromolecules such as micellar thrombin-binding aptamers as anticoagulants.

Definition

5'-O-DMT-2'-Deoxyguanosine(DMF)-CE Phosphoramidite, or DMT-dG(dmf) Phosphoramidite, is a nucleoside amidite analog comprised of 2'-deoxy-N2,5'-O-dimethoxytrityl guanosine (DMF) and 5'-O-dimethoxytrityl cytidine monophosphate (DMT).

DMT-dG(dmf) PhosphoramiditeSupplier

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