6-PHENYLNICOTINIC ACID Chemical Properties

Melting point:

243 °C

Boiling point:

388.1±30.0 °C(Predicted)

Density 

1.241±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

pka

2.19±0.10(Predicted)

color 

White to Light yellow

Safety Information

Hazard Note 

Harmful

HS Code 

2933399990

6-PHENYLNICOTINIC ACID Usage And Synthesis

Synthesis Reference(s)

Journal of the American Chemical Society, 99, p. 3166, 1977 DOI: 10.1021/ja00451a053

Synthesis

Under argon protection, 6-bromonicotinic acid (1 eq.), phenylboronic acid (1.2 eq.) and tetrakis(triphenylphosphine)palladium (1 mol%) were dissolved in a solvent mixture of dioxane and water (10:1 by volume). Potassium carbonate (2 equivalents) was then added and the reaction mixture was heated to reflux for 6 hours. After completion of the reaction, it was cooled to room temperature and the dioxane was removed by rotary evaporator. Water was added and the pH of the solution was adjusted to 1-3 with 2 N hydrochloric acid. the precipitated white solid precipitate was collected by filtration and dried to give 6-phenylnicotinic acid.

References

[1] Inorganic Chemistry, 2012, vol. 51, # 4, p. 2105 - 2114
[2] European Journal of Inorganic Chemistry, 2012, # 7, p. 1025 - 1037
[3] Organic Letters, 2016, vol. 18, # 23, p. 6094 - 6097
[4] European Journal of Medicinal Chemistry, 2017, vol. 137, p. 96 - 107

6-PHENYLNICOTINIC ACID(29051-44-3)Related Product Information

• METHYL 6-PHENYLNICOTINATE
• 6-PHENYLNICOTINONITRILE 97+%3-CYANO-6-PHENYLPIRIDINE
• [4-(METHYLTHIO)PHENYL]HYDRAZINE HYDROCHLORIDE
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• 6-PHENYLNICOTINIC ACID
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• 5-Phenylnicotinic acid, 95+%,5-PHENYLNICOTINIC ACID
• 2-CHLORO-6-(4-FLUOROPHENYL)NICOTINONITRILE
• 2-PHENYLNICOTINIC ACID
• 2-CHLORO-5-PHENYLNICOTINONITRILE
• 2-Methyl-6-phenylnicotinic acid
• ETHYL 6-(4-CHLOROPHENYL)-2-METHYLPYRIDINE-3-CARBOXYLATE
• 2-CHLORO-6-(4-METHOXYPHENYL)NICOTINONITRILE
• 2-METHYL-6-PHENYLNICOTINIC ACID
• 2-HYDROXY-6-PHENYL-3,5-PYRIDINEDICARBOXYLIC ACID
• ETHYL 2-METHYL-6-[3-(TRIFLUOROMETHYL)PHENYL]NICOTINATE
• 2-CHLORO-6-(2-METHYLPHENYL) NICOTINIC ACID
• ETHYL 6-(2,3-DIHYDRO-1H-INDEN-5-YL)-2-METHYLNICOTINATE