2-Propoxybenzoic acid Chemical Properties

Melting point:

35-37°C

Boiling point:

207 °C / 40mmHg

Density 

1.133±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO, Methanol

pka

pK1:4.24 (20°C)

form 

Solid

color 

Off-White

BRN 

3089998

CAS DataBase Reference

2100-31-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36-37

RTECS 

000-000-0

HS Code 

29189900

MSDS

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2-Propoxybenzoic acid Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

2-Propoxybenzoic Acid is a salicylic acid derivative used in the preparation of inhibitors of tyrosinase or hyaluronidase. 2-Propoxybenzoic Acid is a very potent inhibitior of collagen-induced aggregation of human platelets

Synthesis

General procedure for the synthesis of 2-propoxybenzoic acid (PBA) from compound (CAS: 92156-43-9): potassium tert-butoxide (about 11 mmol) was added to a dimethyl sulfoxide (DMSO) solution of compound C (about 9 mmol) and the reaction temperature was maintained at about 0 °C. The reaction mixture was stirred at 0 °C for about 30 minutes, followed by warming up to room temperature (about 25 °C - 30 °C) and continued stirring for 2-3 hours. Upon completion of the reaction, the reaction was quenched with ice water and then extracted with dichloromethane (DCM). The organic layers were combined and dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure. The resulting crude product was purified by recrystallization using ethanol as solvent to afford the target product 2-propoxybenzoic acid (D) with 95% purity.

References

[1] Patent: WO2013/160885, 2013, A1. Location in patent: Page/Page column 16
[2] Patent: US2006/167107, 2006, A1. Location in patent: Page/Page column 4

2-Propoxybenzoic acid(2100-31-4)Related Product Information

• o-Toluic acid
• 4-Methoxybenzoic acid
• 4-Aminobenzoic acid
• Methyl 2-iodobenzoate
• 2-Nitrobenzoic acid
• 2-(Trifluoromethyl)benzoic acid
• Estradiol benzoate
• 2-Iodobenzoic acid
• Benzoic acid
• Benzyl benzoate
• Salicylic acid
• Oxydipropyl dibenzoate
• Citric acid
• Ascoric Acid
• Anthranilic acid
• Metabutoxycaine
• Tienoxolol
• BIS(2-CARBOXYPHENYL) SUCCINATE 95