2-METHYL-4(5)-IODO-1(H)-IMIDAZOLE Chemical Properties

Melting point:

133 °C

Boiling point:

358.2±15.0 °C(Predicted)

Density 

2.094±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

solid

pka

12.30±0.10(Predicted)

Appearance

Off-white to light yellow Solid

InChI

InChI=1S/C4H5IN2/c1-3-6-2-4(5)7-3/h2H,1H3,(H,6,7)

InChIKey

SEDSLMWYUQACGR-UHFFFAOYSA-N

SMILES

C1(C)NC(I)=CN=1

Safety Information

RIDADR 

UN3263

HS Code 

2933299090

2-METHYL-4(5)-IODO-1(H)-IMIDAZOLE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 5-iodo-2-methyl-1H-imidazole from 4,5-diiodo-2-methyl-1H-imidazole was as follows: 4,5-diiodo-2-methyl-1H-imidazole (8.5 g, 25.5 mmol) was dissolved in 430 mL of a 3:7 (v/v) solvent mixture of ethanol and water. Sodium sulfite (25.7 g, 204 mmol) was added to the solution and the reaction mixture was heated to reflux (about 100 °C) for 24 hours. Upon completion of the reaction, the reaction mixture was concentrated to about half of the original volume. The precipitated solid was filtered and washed with cold water to give a final 5.3 g (66% yield) of 5-iodo-2-methyl-1H-imidazole. The product was analyzed by mass spectrometry to confirm that the m/z of the molecular ion peak (M + H)+ was 209.

References

[1] Patent: US2011/230462, 2011, A1. Location in patent: Page/Page column 109
[2] Synthesis, 1994, # 7, p. 681 - 682
[3] Journal of Medicinal Chemistry, 1989, vol. 32, # 7, p. 1552 - 1558
[4] Patent: EP257918, 1988, A1
[5] Patent: US2010/22598, 2010, A1. Location in patent: Page/Page column 27-28

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