METHYLDICHLOROPHOSPHINE Chemical Properties

Melting point:

81.5 °C

Boiling point:

81-82 °C

Density 

1.3

refractive index 

1.4944-1.4964

Flash point:

48 °C

storage temp. 

Flammables area

form 

Liquid

color 

Colorless

Water Solubility 

Reacts with water.

Sensitive 

Air & Moisture Sensitive

InChI

1S/CH3Cl2P/c1-4(2)3/h1H3

InChIKey

CDPKWOKGVUHZFR-UHFFFAOYSA-N

SMILES

CP(Cl)Cl

EPA Substance Registry System

Methylphosphonous dichloride (676-83-5)

Safety Information

Hazard Codes 

T-F,T,F

Risk Statements 

34-29-23/24/25-17-14-10

Safety Statements 

8-45-43-36/37/39-33-26-16-23

RIDADR 

2845

WGK Germany 

3

TSCA 

TSCA listed

HazardClass 

6.1

PackingGroup 

I

HS Code 

29310099

Storage Class

4.2 - Pyrophoric and self-heating hazardous materials

Hazard Classifications

Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Dam. 1
Pyr. Liq. 1
Skin Corr. 1B

MSDS

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METHYLDICHLOROPHOSPHINE Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Uses

Methyldichlorophosphine is used to prepare difunctional phosphonoamidite coupling reagents in nucleoside chemistry and "phospha-Wittig"reagents.

General Description

A colorless liquid with a pungent odor. Very toxic by inhalation. Denser than water.

Air & Water Reactions

Highly flammable. Forms fumes containing HCl in moist air. Can spontaneously ignite on contact with moist air. Reacts with water to form hydrochloric acid, reaction may be violent and ignite unreacted material.

Reactivity Profile

METHYLDICHLOROPHOSPHINE is water reactive. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

Fire will produce irritating, corrosive and/or toxic gases. Inhalation of decomposition products may cause severe injury or death. Contact with substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.

Fire Hazard

Flammable/combustible material. May ignite on contact with moist air or moisture. May burn rapidly with flare-burning effect. Some react vigorously or explosively on contact with water. Some may decompose explosively when heated or involved in a fire. May re-ignite after fire is extinguished. Runoff may create fire or explosion hazard. Containers may explode when heated.

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand

Safety Profile

A poison. A corrosive irritant to the skin, eyes, and mucous membranes. Flammable when exposed to heat or flame; can react vigorously with oxidtzing materials. When heated to decomposition it emits very toxic fumes of Cland POx.

METHYLDICHLOROPHOSPHINE(676-83-5)Related Product Information

• TERT-BUTYLPHOSPHONIC DICHLORIDE
• METHYLDICHLOROPHOSPHINE
• Dichlorophenylphosphine
• 1-PROPANEPHOSPHONIC DICHLORIDE
• 1,2-BIS(DICHLOROPHOSPHINO)ETHANE
• Methyldichlorophosphine oxide
• DICHLOROTRIPHENYLPHOSPHORANE
• tert-Butyldichlorophosphine
• Phenylphosphonic dichloride
• ETHYLDICHLOROPHOSPHINE
• METHYLENEBIS(PHOSPHONIC DICHLORIDE)
• BUTYLPHOSPHONIC DICHLORIDE
• PHENYLTHIOPHOSPHONIC DICHLORIDE
• N-PROPYLDICHLOROPHOSPHINE
• ETHYLPHOSPHONIC DICHLORIDE
• Methyldichlorophosphine sulfide
• ALLYLPHOSPHONIC DICHLORIDE
• HEXYLPHOSPHONIC DICHLORIDE