1-(2-Methoxyphenyl)piperazine hydrochloride Chemical Properties

Melting point:

217-219 °C(lit.)

Boiling point:

130-133C

Density 

1.106g/cm

refractive index 

1,574-1,576

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Soluble in DMSO and Methanol.

form 

A crystalline solid

Sensitive 

Hygroscopic

BRN 

4276925

InChI

InChI=1S/C11H16N2O.ClH/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13;/h2-5,12H,6-9H2,1H3;1H

InChIKey

DDMVHGULHRJOEC-UHFFFAOYSA-N

SMILES

N1(C2=CC=CC=C2OC)CCNCC1.[H]Cl

CAS DataBase Reference

5464-78-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-28A

RIDADR 

UN2811

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

III

HS Code 

29335990

MSDS

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1-(2-Methoxyphenyl)piperazine hydrochloride Usage And Synthesis

Chemical Properties

1-(2-Methoxyphenyl)piperazine hydrochloride is Off-White Solid

Uses

1-(2-Methoxyphenyl)piperazine hydrochloride is used as reference material for forensic laboratories. It is used in chemical synthesis studies.

Synthesis

Procedure for the synthesis of compound 6: In a double necked round bottom flask (RB flask), tert-butyl 4-(2-methoxyphenyl)piperazine-1-carboxylate (Compound 5, 0.600 g, 0.00205 mol, 1 equiv.) was dissolved in ethyl ether (10 mL) followed by addition of ethyl ether hydrochloric acid solution. The reaction mixture was stirred at room temperature overnight. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw material, the ether was removed by evaporation under reduced pressure to give a solid product. The solid product was washed with ethyl acetate and then dried to give the final 1-(2-methoxyphenyl)piperazine hydrochloride (compound 6) as a white solid (0.425 g, 90.08% yield).

References

[1] Patent: US2010/331307, 2010, A1. Location in patent: Page/Page column 19
[2] Patent: WO2011/72174, 2011, A1. Location in patent: Page/Page column 100
[3] Patent: WO2012/3418, 2012, A2. Location in patent: Page/Page column 92

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