NOSCAPINE HYDROCHLORIDE
NOSCAPINE HYDROCHLORIDE Basic information
- Product Name:
- NOSCAPINE HYDROCHLORIDE
- Synonyms:
-
- NOSCAPINE HYDROCHLORIDE
- NARCOTINE HYDROCHLORIDE
- ,3-dioxolo(4,5-g)isoquinolin-5-yl)-,hydrochloride,(s-(r*,s*))-
- 1(3h)isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1
- 1-alpha-narcotinehydrochloride
- capvalhydrochloride
- coscopinhydrochloride
- coscotabshydrochloride
- CAS:
- 912-60-7
- MF:
- C22H24ClNO7
- MW:
- 449.88
- EINECS:
- 213-014-9
- Product Categories:
-
- Inhibitors
- Mol File:
- 912-60-7.mol
NOSCAPINE HYDROCHLORIDE Chemical Properties
- Melting point:
- 221-223 °C(lit.)
- storage temp.
- 2-8°C
- solubility
- Freely soluble in water and in ethanol (96 per cent). Aqueous solutions are slightly acid; the base may be precipitated when the solutions are allowed to stand.
- form
- Solid
- color
- Crystals
- Merck
- 13,6752
- InChIKey
- MFLVZFXCSKVCSH-FSKSRBAZNA-N
- SMILES
- C12=C(CCN(C)[C@@]1([H])[C@@]1([H])OC(=O)C3C(OC)=C(OC)C=CC1=3)C=C1OCOC1=C2OC.Cl |&1:6,8,r|
- EPA Substance Registry System
- 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride, (3S)- (912-60-7)
MSDS
- Language:English Provider:SigmaAldrich
NOSCAPINE HYDROCHLORIDE Usage And Synthesis
Chemical Properties
White or almost white, crystalline powder or colourless crystals, hygroscopic.
Uses
Anti-Tussive
Uses
Noscapine Hydrochloride is a bradykinin B and tubulin inhibitor. Anti-viral.
Uses
topical fluoroquinolone antibiotic for acne
Biological Activity
Opioid alkaloid with several actions. Binds to tubulin, arresting cells in mitosis and inducing apoptosis. Also is an antagonist at bradykinin receptors (pA 2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated increases in cAMP levels in CNS tissues. Clinically used antitussive agent.
Safety Profile
Poison by intravenous route.Moderately toxic by ingestion and subcutaneous routes.Mutation data reported. When heated to decomposition itemits very toxic fumes of HCl and NOx.
in vivo
Noscapine (300?mg/kg; oral gavage; daily; for 15 days; athymic female mice) hydrochloride treatment reduces tumor growth in mice[1].
| Animal Model: | Athymic female mice (nu/nu) (8-week-old) injected with rat C6 glioma cells[1] |
| Dosage: | 300?mg/kg |
| Administration: | Oral gavage; daily; for 15 days |
| Result: | Revealed a significant reduction of tumor volume. |
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NOSCAPINE HYDROCHLORIDE(912-60-7)Related Product Information
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