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NOSCAPINE HYDROCHLORIDE

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NOSCAPINE HYDROCHLORIDE Basic information

Product Name:
NOSCAPINE HYDROCHLORIDE
Synonyms:
  • NOSCAPINE HYDROCHLORIDE
  • NARCOTINE HYDROCHLORIDE
  • ,3-dioxolo(4,5-g)isoquinolin-5-yl)-,hydrochloride,(s-(r*,s*))-
  • 1(3h)isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1
  • 1-alpha-narcotinehydrochloride
  • capvalhydrochloride
  • coscopinhydrochloride
  • coscotabshydrochloride
CAS:
912-60-7
MF:
C22H24ClNO7
MW:
449.88
EINECS:
213-014-9
Product Categories:
  • Inhibitors
Mol File:
912-60-7.mol
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NOSCAPINE HYDROCHLORIDE Chemical Properties

Melting point:
221-223 °C(lit.)
storage temp. 
2-8°C
solubility 
Freely soluble in water and in ethanol (96 per cent). Aqueous solutions are slightly acid; the base may be precipitated when the solutions are allowed to stand.
color 
Crystals
Merck 
13,6752
EPA Substance Registry System
1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride, (3S)- (912-60-7)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22
Safety Statements 
36
RIDADR 
1544
WGK Germany 
3
RTECS 
NP7225000
F 
10
HS Code 
2939.19.5000
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
cyt-ham:fbr 60 mg/L ESKHA5 96,55,78

MSDS

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NOSCAPINE HYDROCHLORIDE Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder or colourless crystals, hygroscopic.

Uses

Anti-Tussive

Uses

Noscapine Hydrochloride is a bradykinin B and tubulin inhibitor. Anti-viral.

Uses

topical fluoroquinolone antibiotic for acne

Biological Activity

Opioid alkaloid with several actions. Binds to tubulin, arresting cells in mitosis and inducing apoptosis. Also is an antagonist at bradykinin receptors (pA 2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated increases in cAMP levels in CNS tissues. Clinically used antitussive agent.

Safety Profile

Poison by intravenous route.Moderately toxic by ingestion and subcutaneous routes.Mutation data reported. When heated to decomposition itemits very toxic fumes of HCl and NOx.

NOSCAPINE HYDROCHLORIDESupplier

Qinghai Pharmaceutical Factory Co., Ltd. Gold
Tel
0971-5506700
Email
xcf@qhzhiyao.com、sqj@qhzhiyao.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Email
Sales-CN@TCIchemicals.com
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
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