N-Boc-2-piperidinecarboxylic acid Chemical Properties

Melting point:

130-133 °C (lit.)

Boiling point:

353.2±35.0 °C(Predicted)

Density 

1.164±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

pka

4.03±0.20(Predicted)

form 

Crystalline Powder

color 

White

BRN 

480022

InChI

InChI=1S/C11H19NO4/c1-11(2,3)16-10(15)12-7-5-4-6-8(12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)

InChIKey

JQAOHGMPAAWWQO-UHFFFAOYSA-N

SMILES

N1(C(OC(C)(C)C)=O)CCCCC1C(O)=O

CAS DataBase Reference

98303-20-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

10

HazardClass 

IRRITANT

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

N-Boc-2-piperidinecarboxylic acid Usage And Synthesis

Chemical Properties

White crystalline powder

Uses

DL-Boc-pipecolic acid is the protected form of Pipecolic acid (P479760). Pipecolic acid is an intemediary metabolite of L-Lysine (L468895). Its accumulation in the body is characteristic of peroxisomal disorders in infants (such as Zeilweiger syndrome). Pipecolic acid is also used as a catalyst in asymmetric Mannich reactions.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

References

[1] Tetrahedron Letters, 1996, vol. 37, # 20, p. 3441 - 3444
[2] Patent: WO2004/14902, 2004, A2. Location in patent: Page 45
[3] Organic Letters, 2013, vol. 15, # 4, p. 824 - 827
[4] Journal of Organic Chemistry, 2005, vol. 70, # 15, p. 5954 - 5963
[5] Journal of Organic Chemistry, 1999, vol. 64, # 6, p. 1993 - 2002

N-Boc-2-piperidinecarboxylic acid(98303-20-9)Related Product Information

• Folic acid
• Glycine
• 2-Piperidone
• 2,3,4-Trihydroxybenzoic acid
• DL-Pipecolinic acid
• Ethyl 2-(Chlorosulfonyl)acetate
• DL-Malic acid
• 2,4-Dichlorobenzoic acid
• Haloperidol
• Pirenzepine hydrochloride
• DI-TERT-BUTYL ETHER
• N-BOC-3-PIPERIDINECARBOXYLIC ACID
• Ethyl 1-Boc-piperidine-2-carboxylate
• N-BOC-4-Piperidinecarboxylic acid,1-BOC-4-PIPERIDINECARBOXYLIC ACID
• Ethyl N-Boc-piperidine-4-carboxylate
• 1-Boc-3-Piperidinecarboxylic acid ethyl ester
• 1-N-BOC-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER,N-BOC-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER
• N-BOC-3-Aminopiperidine