L-2-AMINO-4-SULFOBUTYRIC ACID
L-2-AMINO-4-SULFOBUTYRIC ACID Basic information
- Product Name:
- L-2-AMINO-4-SULFOBUTYRIC ACID
- Synonyms:
-
- L-HOMOCYSTEIC ACID
- L-2-AMINO-4-SULFOBUTYRIC ACID
- (S)-2-Amino-4-sulfobutanoic acid
- Butanoic acid, 2-amino-4-sulfo-, (2S)-
L -Homocysteic acid
- CAS:
- 14857-77-3
- MF:
- C4H9NO5S
- MW:
- 183.18
- Mol File:
- 14857-77-3.mol
L-2-AMINO-4-SULFOBUTYRIC ACID Chemical Properties
- Density
- 1.638±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- form
- powder
- pka
- 1.40±0.50(Predicted)
- color
- white to off-white
MSDS
- Language:English Provider:SigmaAldrich
L-2-AMINO-4-SULFOBUTYRIC ACID Usage And Synthesis
Uses
L-Homocysteic acid has been used to study hydrogen peroxide-mediated changes in physiological and pathological conditions in the nervous system.
Definition
ChEBI: A homocysteic acid with L-configuration.
Biochem/physiol Actions
L-Homocysteic acid (L-HCA) is an endogenous neurotransmitter ligand of NMDA (N-methyl-D-aspartate) receptors. It is an analog of glutamate and competitively suppresses glutamate-cystine (xc-) antiporter function in neurons, causing decrease in cysteine uptake.
in vivo
L-Homocysteic acid (intraperitoneal injection, 4-11 mmol/kg) elicits seizures in rats during early postnatal development[4].
L-Homocysteic acid (intraperitoneal injection, 100-1500 mg/kg) partially substitutes for NMDA, producing maximum values of 61-67% NMDA-lever responding at doses of 1000 and 560 mg/kg, respectively in Sprague-Dawley rats[5].
| Animal Model: | Male albino rats of the Wistar strain[4] |
| Dosage: | 4, 5.5, 8, 11 mM/kg |
| Administration: | Intraperitoneal injection, daily for 14 days |
| Result: | Induced flexion seizures at 4 mmol/kg. Led to intense tail flicking, pivoting, and locomotion. Decreased ECoG (electrocorticograms) activity for 5-9 min. |
IC 50
NMDA Receptor: 14 μM (EC50)
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