Ergonovine maleate Chemical Properties

Melting point:

167 °C (decomp)

alpha 

D25 +48 to +57°

Boiling point:

552.4°C (rough estimate)

Density 

1.2948 (rough estimate)

refractive index 

1.6500 (estimate)

storage temp. 

−20°C

Stability:

Stable, but may be heat sensitive - store at -20 C. Incompatible with strong oxidizing agents.

Safety Information

Hazard Codes 

T

Risk Statements 

23/24/25

Safety Statements 

36/37-45

RIDADR 

UN 1544 6.1/PG 2

WGK Germany 

3

RTECS 

KE5250000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29396100

Toxicity

LD50 i.v. in mice: 8.26 mg/kg (Beliles)

Ergonovine maleate Usage And Synthesis

Chemical Properties

white solid

Uses

Ergonovine is an oxytocic, stimulates contraction of uterine muscle; partial agonist at serotonergic and dopaminergic receptors in CNS; selective, potent antagonist at smooth muscle serotonergic receptors.

Definition

ChEBI: A maleate salt resulting form the reaction of equimolar amounts of maleic acid and ergometrine. It is used in the active management of the third stage of labour, and to prevent or treat postpartum of postabortal haemorrhage caused by uterine atony: by main aining uterine contraction and tone, blood vessels in the uterine wall are compressed and blood flow reduced.

brand name

Ergotrate Maleate (Lilly).

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