DMT-2'O-TBDMS-rA(bz) Phosphoramidite
DMT-2'O-TBDMS-rA(bz) Phosphoramidite Basic information
- Product Name:
- DMT-2'O-TBDMS-rA(bz) Phosphoramidite
- Synonyms:
-
- DMT-2′O-TBDMS-rA(bz) Phosphoramidite
- 2'-TBDMS -Bz-rA-CE-Phosphoramidite
- 5'-DMT-2'-O-TBDMS- N6-Benzoyl-Adenosine Phosphoramidite
- (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(tert-butyldimethylsilyloxy)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite
- REF DUPL: 2'-TBDMS-rA(N-Bz)Phosphoramidite
- Bz-rA Phosphoramidite
- N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine 3'-CE phosphoramidite
- 5'-O-(4,4'-DiMethoxy)-N6-benzoyl-2'-O-(t-butyl diMethylsilyl)adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoraMidite
- CAS:
- 104992-55-4
- MF:
- C53H66N7O8PSi
- MW:
- 988.19
- EINECS:
- 2017-001-1
- Product Categories:
-
- Pharmaceutical
- Amidite
- Mol File:
- 104992-55-4.mol
DMT-2'O-TBDMS-rA(bz) Phosphoramidite Chemical Properties
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- powder
- pka
- 7.87±0.43(Predicted)
- color
- white to off-white
- InChI
- InChI=1/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/s3
- InChIKey
- FFXHNCNNHASXCT-RFMFGJHUSA-N
- SMILES
- O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C3=C(C(=NC=N3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](O[Si](C(C)(C)C)(C)C)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N |&1:25,27,46,55,r|
DMT-2'O-TBDMS-rA(bz) Phosphoramidite Usage And Synthesis
Uses
N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite can be used as Organic synthesis intermediates and pharmaceutical intermediates are mainly used in laboratory research and development processes and chemical production processes.
Uses
DMT-2''O-TBDMS-rA(bz) Phosphoramidite (DMT-2'O-TBDMS-rA(bz) Phosphoramidite) is a 2''-O-Protected ribonucleoside phosphoramidite used as a key raw material for the automated solid-supported synthesis of oligonucleotide-based drugs. It is also used to synthesize 2''-O-guanidinopropyl-modified nucleoside phosphoramidites to incorporate into siRNAs targeting hepatitis B virus.
Synthesis
To a solution of 72 (12.0 g, 15.2 mmoi) in DIPEA (15 ml) and DCM (30 mL) is added DMAP (744 mg, 6.09 rnrnol) and 2cyanoethyl JV.Ndiisopropylchlorophosphoramidite (5.41 g, 22.9 rnmoi) at 25 ℃. After stirring for 2 hours, the mixture is purified directly by basic silica gel column chromatography (EAIPE 1/4 toi/1) to give DMT-2'O-TBDMS-rA(bz) Phosphoramidite as a white solid (13.0 g. 86% yield)
DMT-2'O-TBDMS-rA(bz) PhosphoramiditeSupplier
- Tel
- 021-64757213
- info@hongene.com
- Tel
- 0553-0553-5842013-801 18155347026
- sale@huarensh.com
- Tel
- 021-58648778 18217200601
- bush@perno.cn
- Tel
- info@bocsci.com
- Tel
- 13335632219
- 3152731197@qq.com
DMT-2'O-TBDMS-rA(bz) Phosphoramidite(104992-55-4)Related Product Information
- BENZOYL ISOCYANATE
- Buprofezin
- ADENOSINE 5'-TRIPHOSPHATASE
- tert-Butanol
- Benzoyl chloride
- Cyhalofop-butyl
- Benzoyl peroxide
- Dimethyldimethoxysilane
- tert-Butyl acetate
- tert-Butyldimethylsilyl chloride
- tert-Butyl peroxyacetate
- N-Benzoylaminopurine
- 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYADENOSINE
- TERT-BUTYLDIMETHYLSILANOL
- N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine
- N6-BENZYLADENOSINE
- N6-BENZOYL-3'-DEOXYADENOSINE
- DIMETHYL N,N-DIISOPROPYLPHOSPHORAMIDITE