Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)- Chemical Properties

Density 

1.371

storage temp. 

2-8°C

solubility 

DMSO: >15mg/mL

form 

powder

color 

yellow

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

WGK Germany 

3

Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)- Usage And Synthesis

Uses

Nucleozin may be used in anti-viral (anti-influenza) research to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an influenza A nucleoprotein (a multifunctional, RNA-binding protein necessary for virus replication) targeting drug candidate.

Biological Activity

Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication. Nucleozin is effective in fighting H1N1, H3N2, and H5N1 flu virus strains by inducing the formation of NP aggregates and antagonizing its nuclear accumulation, leading to cessation of viral replication.', 'Nucleozin targets influenza A nucleoprotein, a multifunctional, RNA-binding protein necessary for virus replication. It induces the formation of nucleoptotein aggregates and inhibits its accumulation, interfering with viral replication. EC50 is in the nM range. Nucleozin is effective in H1N1, H3N2, and H5N1 flu virus strains.

target

Influenza Virus NP

Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)-(341001-38-5)Related Product Information

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