Sodium tetradecyl sulfate Chemical Properties

Melting point:

199 °C

storage temp. 

Store at -20°C

form 

Micro-Crystalline Powder

color 

White

PH

pH : 5.5～7.5 (1%）

Water Solubility 

Soluble in water.

Sensitive 

Hygroscopic

BRN 

3578122

Stability:

Stable. Incompatible with strong oxidizing agents.

InChI

InChI=1S/C14H30O4S.Na.H/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-18-19(15,16)17;;/h2-14H2,1H3,(H,15,16,17);;

InChIKey

BNJXCWISOPKMCW-UHFFFAOYSA-N

SMILES

C(COS(O)(=O)=O)CCCCCCCCCCCC.[NaH]

CAS DataBase Reference

1191-50-0(CAS DataBase Reference)

EPA Substance Registry System

Sodium tetradecyl sulfate (1191-50-0)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

2

RTECS 

XB8660000

TSCA 

Yes

HS Code 

29041000

Toxicity

mouse,LD50,intraperitoneal,342mg/kg (342mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION,Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 283, 1953.

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Sodium tetradecyl sulfate Usage And Synthesis

Chemical Properties

SODIUM TETRADECYL SULFATE is white solid

Uses

Foaming, wetting, and emulsifying in cosmetic, household, and industrial uses.

Uses

Sodium 1-tetradecyl sulfate is used as an anionic surfactant in nickel plating bath, pickling, electrolytic cleaning, welding, leather dyeing and rubles polishes. It is used to study the time course of liquid drainage and foam coarsening and to investigate the effects of sclerosant foam preparation. It is used for the treatment of varicose and spider veins of the leg.

brand name

Sotradecol (Bioniche); Sotradecol (Elkins-Sinn).

General Description

Tetradecyl sulfate sodium salt is a detergent-like sclerosant.

Clinical Use

Sodium tetradecyl sulfate has shown efficacy in treating varicose veins, telangiectasias, hemangioma, pyogenic granuloma, cherry angioma, Kaposi sarcoma, lymphangioma circumscriptum, digital mucous cyst, ganglion cyst, glomangioma, angiokeratoma of Fordyce, pseudocyst of the auricle, and verruca[1].

Side effects

Commonly reported side effects include pain, erythema, swelling, hyperpigmentation, telangiectatic matting, and ulceration. Serious side effects such as anaphylaxis, pulmonary embolism, stroke, and myocardial infarction have also been reported.

Safety Profile

Poison by intraperitoneal and intravenous routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and Na2O. See also SULFATES

Purification Methods

It recrystallises from absolute EtOH [Abu Hamdiyyah & Rahman J Phys Chem 91 1531 1987]. Itis hygroscopic.[Beilstein 1 H 716.]

References

[1] Helena A Jenkinson, Sirunya Silapunt, Kelly M Wilmas. “Sodium Tetradecyl Sulfate: A Review of Clinical Uses.” Dermatologic Surgery 43 11 (2017): 1313–1320.

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