3-(2-Fluorophenyl)propionic acid Chemical Properties

Melting point:

74-78 °C

Boiling point:

273.7±15.0 °C(Predicted)

Density 

1.222±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

solid

pka

4.65±0.10(Predicted)

Appearance

White to light yellow Solid

InChIKey

GUZLQEOSDXLCKX-UHFFFAOYSA-N

CAS DataBase Reference

1643-26-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36/37/39

WGK Germany 

3

Hazard Note 

Corrosive

HazardClass 

IRRITANT, CORROSIVE

HS Code 

29163990

3-(2-Fluorophenyl)propionic acid Usage And Synthesis

Chemical Properties

Off-white solid

Synthesis

c) Preparation of 3-(2-fluorophenyl)propionic acid A mixture of ethyl 3-(2-fluorophenyl)propionate (25.54 g, 0.130 mol) with 50% aqueous sodium hydroxide solution (30 mL) in water (130 mL) was refluxed for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently washed with ether (2 x 100 mL) to remove organic impurities. The aqueous phase was cooled in an ice bath and the pH was adjusted to 3 by slow dropwise addition of hydrochloric acid to promote precipitation of 3-(2-fluorophenyl)propionic acid. The white precipitate formed was collected by filtration and washed several times with water to remove residual inorganic salts. Finally, the product was dried under vacuum at 60 °C for 18 h to afford 18.66 g (85% yield) of 3-(2-fluorophenyl)propionic acid as a white solid with a melting point of 72°-74 °C. The purity of the product met the requirements for subsequent use without further purification.

References

[1] Patent: US5872118, 1999, A

3-(2-Fluorophenyl)propionic acid(1643-26-1)Related Product Information

• Calcium Propionate
• Propionic anhydride
• Propionic acid
• (S)-(+)-2-Phenylpropionic acid
• Perfluoropropionic acid
• Fluticasone propionate
• Ethyl 2-(Chlorosulfonyl)acetate
• Folic acid
• Citric acid
• Ascoric Acid
• Methyl pentafluoropropionate
• 2-AMINO-3-(2-FLUOROPHENYL)PROPIONIC ACID
• 2,5-DIFLUORO-DL-PHENYLALANINE
• 2-FLUORO-D-PHENYLALANINE
• 3-(2-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
• (S)-2-AMINO-3-(2-FLUOROPHENYL)PROPIONIC ACID
• BOC-(S)-3-AMINO-3-(4-FLUORO-PHENYL)-PROPIONIC ACID
• 3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID