2'-HYDROXY-2,3-DIMETHOXYCHALCONE Chemical Properties

Melting point:

100～102℃

Boiling point:

453.2±45.0 °C(Predicted)

Density 

1.203±0.06 g/cm3(Predicted)

pka

7.66±0.30(Predicted)

form 

solid

LogP

3.890 (est)

Safety Information

Risk Statements 

20/21/22

Safety Statements 

26-36

2'-HYDROXY-2,3-DIMETHOXYCHALCONE Usage And Synthesis

Uses

α-Gracinoic acid is a Chalcone (HY-121054) derivative with anti-inflammatory activity. α-Gracinoic acid inhibits nitric oxide production catalyzed by inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-treated RAW 264.7 cells[1].

References

[1] Kim, et al. "Anti-inflammatory activity of the synthetic chalcone derivatives: inhibition of inducible nitric oxide synthase-catalyzed nitric oxide production from lipopolysaccharide-treated RAW 264.7 cells." Biological and Pharmaceutical Bulletin 30.8 (2007): 1450-1455. DOI:10.1248/bpb.30.1450

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