5-Fluoroisatin Chemical Properties

Melting point:

224-227 °C (lit.)

Density 

1.477±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, DMSO, Methanol

pka

8.51±0.20(Predicted)

form 

Powder

color 

Red

BRN 

131241

InChIKey

GKODDAXOSGGARJ-UHFFFAOYSA-N

CAS DataBase Reference

443-69-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29337900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

5-Fluoroisatin Usage And Synthesis

Chemical Properties

red Crystalline Powder

Uses

Reactant for preparation of:

• Spiro[indole-thiazolidinones] as biologically relevan synthesis scaffolds
• Potential antimycobacterial agents
• Inhibitors of c-Met kinase
• Inhibitors of TAK1 kinase
• Herpes simplex virus inhibitors
• IKKβ inhibitors
• Inhibitors of vitiligo disease
• Potential drug candidates with anti-HIV activity and anti-tubercular activity

Uses

It showed antibacterial and antifungal activities.

Definition

ChEBI: 5-Fluoroisatin is a member of indoles. It has a role as an anticoronaviral agent.

General Description

5-Fluoroisatin has been reported as the precursor of the Sunitinib (Sutent) drug. 5-Fluoroisatin has been approved by the Food and Drugs Administration (FDA) in 2006 for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST).

5-Fluoroisatin (443-69-6)Related Product Information

• Isatin
• Indole-3-acetic acid
• Dehydroepiandrosterone
• 5-Fluoroindole
• Isophorone
• 5-Fluoro-2-oxindole
• Isatoic Anhydride
• cis-Octahydroisoindole
• 6-Chloro-5-fluoroindole
• Indirubin
• Indometacin
• Naringin dihydrochalcone
• Indole-3-butyric acid
• 1-(2,6-Dichlorophenyl)indolin-2-one
• 5,6-DIFLUOROISATIN
• 5-FLUORO-6-CHLORO ISATIN
• 6-Fluoroisatoic anhydride
• 5-Fluoro-7-Methyl Isatin