2-PHENYLMELATONIN Chemical Properties

storage temp. 

Desiccate at +4°C

solubility 

Soluble to 100 mM in ethanol and to 100 mM in DMSO

form 

Powder

2-PHENYLMELATONIN Usage And Synthesis

Uses

2-Phenylmelatonin is a melatonin receptor binder with mixed agonist/antagonist activity.

Definition

ChEBI: N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide is a phenylindole.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 38, p. 1132, 1995 DOI: 10.1021/jm00007a010

Biological Activity

Highly potent melatonin agonist; displays higher affinity and greater potency than melatonin itself. The EC 50 values for G protein activation in MT 1 and MT 2 -transfected cells are 65 and 58 pM respectively.

storage

Desiccate at +4°C

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