1,2,4-Trimethoxybenzene Chemical Properties

Boiling point:

247 °C(lit.)

Density 

1.126 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.533(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, Ethyl Acetate

form 

Oil

color 

Clear Colourless

Water Solubility 

Not miscible in water.

Merck 

14,1073

BRN 

2047579

LogP

1.640 (est)

CAS DataBase Reference

135-77-3(CAS DataBase Reference)

NIST Chemistry Reference

1,2,4-Trimethoxybenzene(135-77-3)

EPA Substance Registry System

1,2,4-Trimethoxybenzene (135-77-3)

Safety Information

Hazard Codes 

Xi

Safety Statements 

23-24/25

WGK Germany 

3

RTECS 

DC2770000

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29093090

MSDS

• Language:English Provider:1,2,4-Trimethoxybenzene
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1,2,4-Trimethoxybenzene Usage And Synthesis

Chemical Properties

clear light yellow to yellow-brown liquid

Uses

1,2,4-Trimethoxybenzene is used as a reagent in the synthesis of barbigerone derivatives which can be used as antiproliferative and antiangiogenesis agents. Also used as a reagent in the synthesis of Malvone A (M161525) which is a phytoalexin found in Malva sylvestris.

Definition

ChEBI: 1,2,4-Trimethoxybenzene is a member of methoxybenzenes.

1,2,4-Trimethoxybenzene (135-77-3)Related Product Information

• (Trifluoromethoxy)benzene
• p-Anisaldehyde
• 4-Methoxybenzyl alcohol
• 4-Methoxybenzoic acid
• 4-Methoxybenzyl cyanide
• 4'-Methoxyacetophenone
• 1,2,4-Trimethylbenzene
• Anisole
• 4-Methoxybenzoyl chloride
• 3-Methoxyphenethylamine
• 1,3,5-TRIMETHOXYBENZENE pure,sym-Trimethoxybenzene
• 1,2,3-TRIMETHOXYBENZENE
• 6,7-DIMETHOXY-4-METHYLCOUMARIN
• FRAXIN
• β-Asarone, cis-1-Propenyl-2,4,5-trimethoxybenzene
• 2,4,5-Trimethoxybenzoic acid
• 2,4,5-Trimethoxybenzaldehyde
• 3,4,5-Trimethoxy benzoic acid