3-Methoxyphenylboronic acid Chemical Properties

Melting point:

160-163 °C (lit.)

Boiling point:

318.6±44.0 °C(Predicted)

Density 

1.17±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

8.10±0.10(Predicted)

form 

Crystalline Powder

color 

White to light beige

BRN 

2831223

InChI

InChI=1S/C7H9BO3/c1-11-7-4-2-3-6(5-7)8(9)10/h2-5,9-10H,1H3

InChIKey

NLLGFYPSWCMUIV-UHFFFAOYSA-N

SMILES

B(C1=CC=CC(OC)=C1)(O)O

CAS DataBase Reference

10365-98-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29319090

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3-Methoxyphenylboronic acid Usage And Synthesis

Chemical Properties

3-Methoxyphenylboronic acid is a white to light yellow crystal powder, irritating.

Uses

suzuki reaction

Uses

3-Methoxyphenylboronic Acid is a phenylboronic acid used to investigate boron function in plants.

Synthesis

Phase I: Synthesis of 3-methoxyphenylboronic acid 1. 41.3 g (220 mmol) of m-bromoanisole was dissolved in 880 mL of tetrahydrofuran under nitrogen protection and the solution was cooled to -70 °C in an ethanol/dry ice cooling bath. 2. 160 mL (250 mmol) of butyllithium solution (1.6 M in hexane) was added slowly dropwise, with the rate of acceleration of the drop being controlled to ensure that the reaction temperature did not exceed -60 °C. 3. After stirring the reaction mixture continuously for 1.5 hours at -70 °C, slowly add 75 mL (660 mmol) of trimethyl borate dropwise, again controlling the temperature to not exceed -60 °C. 4. 4. After the dropwise addition, the reaction mixture was continued to be stirred for 1 hour under cooling conditions. 5. The reaction mixture was slowly warmed to 25 °C over a period of 2 hours, followed by the addition of 720 mL of 1 M hydrochloric acid and stirring at 25 °C for 15 hours. 6. Upon completion of the reaction, post-treatment was performed: the reaction mixture was extracted with 300 mL of ether, repeated three times, and the organic phases were combined. 7. The combined organic phases were washed sequentially with 100 mL of water and saturated sodium chloride solution, then dried with anhydrous magnesium sulfate and filtered. 8. The filtrate was concentrated on a rotary evaporator (pressure controlled at 500-10 mbar) to give 30.8 g of 3-methoxyphenylboronic acid in 92.1% yield of the theoretical value.

References

[1] Patent: US2002/198251, 2002, A1
[2] Tetrahedron Letters, 2012, vol. 53, # 46, p. 6182 - 6185,4
[3] Journal of the Chemical Society - Perkin Transactions 1, 1999, # 17, p. 2513 - 2523
[4] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 9, p. 1919 - 1922

3-Methoxyphenylboronic acid(10365-98-7)Related Product Information

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• 4-Methoxybenzoyl chloride
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