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Carbazochrome sodium sulfonate

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Carbazochrome sodium sulfonate Basic information

Product Name:
Carbazochrome sodium sulfonate
Synonyms:
  • 1-METHYL-6-OXO-2,3,5,6-TETRAHYDROINDOLE-5-SEMICARBAZONO-2-SULFONIC ACID SODIUM SALT 3 HYDRATE
  • CARBAZOCHROME SODIUM SULFONATE
  • CARBAZOCHROME SODIUM SULFONATE TRIHYDRATE
  • adonatrihydrate
  • adrenochromesulfonateac17trihydrate
  • sodium1-methyl-5-semicarbazono-6-oxo-2,3,5,6-tetrahydroindole-3-sulfonate
  • thyl-6-oxo-,monosodiumsalt,trihydrate
  • CARBAZOCHROMESODIUMSULPHONATE
CAS:
51460-26-5
MF:
C10H17N4NaO8S
MW:
376.32
EINECS:
257-217-0
Product Categories:
  • Miscellaneous
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Analgesic series
  • 51460-26-5
Mol File:
51460-26-5.mol
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Carbazochrome sodium sulfonate Chemical Properties

Melting point:
approximate 210℃(dec.)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Sparingly), Methanol (Slightly)
form 
Solid
color 
Yellow to Dark Orange
PH
pH (16g/l, 25℃) 5.0～6.0
Stability:
Hygroscopic, Moisture Sensitive, Temperature Sensitive
InChIKey
HLFCZZKCHVSOAP-DAMYXMBDSA-M
SMILES
C12=C/C(/C(=O)C=C1N(C(S([O-])(=O)=O)C2)C)=N\NC(=O)N.O.O.O.[Na+]
CAS DataBase Reference
51460-26-5(CAS DataBase Reference)
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Carbazochrome sodium sulfonate Usage And Synthesis

Chemical Properties

Carbazochrome sodium sulfonate is Yellow Solid

Uses

Carbazochrome is an antihemorrhagic for use in the treatment of hemorrhoids.

Uses

Carbazochrome Sodium Sulfonate Hydrate is a phosphatidylinositol hydrolysis inhibitor in endothelial cells.

Uses

Carbazochrome sodium sulfonate is a Phosphatidylinositol hydrolysis inhibitor in endothelial cells.

in vivo

Carbazochrome inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media. Carbazochrome (1-10 mg/kg, i.v.) attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats[2].

Animal Model:Male Sprague-Dawley rats weighing 180-230 g[2]
Dosage:1, 5 and 10 mg/kg
Administration:I.v.; injected 30, 60, or 90 min before Ioxaglate injection (4 g I/kg, i.v.).
Result:Attenuated the Ioxaglate-increased vascular permeability at the dose of 1, 5 and 10 mg/kg in a dose-dependent manner, achieving statistical significance at 5 and 10 mg/kg.

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