ansamitocin P-3 Chemical Properties

Melting point:

190-192℃

Boiling point:

833.1±65.0 °C(Predicted)

Density 

1.29

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO: 100 mg/mL (157.45 mM);Ethanol: 55 mg/mL (86.60 mM)

pka

9.82±0.70(Predicted)

form 

Solid

color 

White to Off-White

Water Solubility 

Water: Insoluble

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

OQ2293000

HS Code 

2941900000

ansamitocin P-3 Usage And Synthesis

Description

Ansamitocin P 3 is a macrocyclic antitumor antibiotic that works by depolymerizing microtubules in both interphase and mitosis, and perturbs chromosome segregation.

Uses

Ansamitocin P-3 is an antitumor agent that binds to cell division protein FtsZ in Actinosynnema pretiosum.

Definition

ChEBI: A polyketide antibiotic that is isolated from Actinosynnema pretiosum and also exhibits antitumour activity.

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