cis-Octahydro-1H-isoindole hydrochloride Chemical Properties

Melting point:

121-123 °C

storage temp. 

Sealed in dry,Room Temperature

InChI

InChI=1/C8H15N.ClH/c1-2-4-8-6-9-5-7(8)3-1;/h7-9H,1-6H2;1H/t7-,8+;

InChIKey

CLQIZUYXKFTUEB-KVZVIFLMNA-N

SMILES

[H][C@]12CCCC[C@@]1([H])CNC2.Cl |&1:1,6,r|

Safety Information

HS Code 

2933998090

cis-Octahydro-1H-isoindole hydrochloride Usage And Synthesis

Description

Cis-Octahydro-1H-isoindole hydrochloride is an important intermediate in the synthesis of mitiglinide which is a new oral hypoglycemic drug for the treatment of type II diabetes for the first marked in Japan

Preparation

Phthalimide was used as raw material to react with KOH. Benzyl bromide was subsequently added to the solution to obtain the N-benzylphthalimide. The addition of lithium tetrahydroaluminum, reducing compound N-benzylphthalimide, yields N-benzyldihydroisoindole. Finally, cis-Octahydro-1H-isoindole hydrochlorid is obtained by Pd/C catalysis and reduction

cis-Octahydro-1H-isoindole hydrochloride(161829-92-1)Related Product Information

• Pyridoxamine dihydrochloride
• Ethylene thiourea
• Dicaprylyl carbonate
• Terbinafine
• Chromium nicotinate
• Benzamidine hydrochloride
• Pentamethyldiethylenetriamine
• 1,1'-Carbonyldiimidazole