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ChemicalBook >  Product Catalog >  Biochemical Engineering >  Inhibitors >  Neuronal Signaling >  COX inhibitors >  10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid

10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid

Basic information Safety Supplier Related

10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid Basic information

Product Name:
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid
Synonyms:
  • 2-(6-oxo-5H-benzo[b][1]benzothiepin-3-yl)propanoic acid
  • Zaltoprofen/ 10,11-Dihydro-alpha-Methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid
  • Zaltoprofen, >=99%
  • Salafapinon
  • Soleton
  • Dibenzo(B,F)thiepin-2-acetic acid, 10,11-dihydro-alpha-methyl-10-oxo-
  • Einecs 277-973-5
  • Zaltoprofen (unspecified)
CAS:
74711-43-6
MF:
C17H14O3S
MW:
298.36
EINECS:
277-973-5
Product Categories:
  • Inhibitors
  • Zaltoprofen
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
74711-43-6.mol
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10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid Chemical Properties

Melting point:
129-1310C
Boiling point:
500.5±50.0 °C(Predicted)
Density 
1.329±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.21±0.10(Predicted)
color 
Off-White to Pale Yellow
Merck 
14,10112
InChI
InChI=1S/C17H14O3S/c1-10(17(19)20)11-6-7-15-12(8-11)9-14(18)13-4-2-3-5-16(13)21-15/h2-8,10H,9H2,1H3,(H,19,20)
InChIKey
MUXFZBHBYYYLTH-UHFFFAOYSA-N
SMILES
C(C1=CC=C2SC3=CC=CC=C3C(CC2=C1)=O)(C)C(=O)O
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Safety Information

RTECS 
HQ2526700
HS Code 
2934.99.4400
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10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid Usage And Synthesis

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Zaltoprofen is a non-steroidal anti-inflammatory drug. It inhibits bradykinin-induced pain responses without blocking bradykinin receptors.

Uses

Anti-inflammatory activity resides in (S)-enantiomer.

Definition

ChEBI: Zaltoprofen is an organic molecular entity.

in vivo

Zaltoprofen (5-20 mg/kg; a single p.o.) inhibits bradykinin-induced nociceptive responses in rats[2].
Zaltoprofen (3-30 mg/kg; a single p.o.) inhibits the acetic acid-induced writhing response of mice in a dose-dependent manner[2].

Animal Model:Eight-week-old male Wistar rats were injected Bradykinin every 15 min[2]
Dosage:5, 10, 20 mg/kg
Administration:A single p.o.
Result:Inhibited bradykinin-induced nociceptive responses, with an ED50 of 9.7 mg/kg.
The duration of analgesic effect was 60-90 min.

IC 50

COX-2: 0.34 μM (IC50); COX-1: 1.3 μM (IC50)

10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acidSupplier

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