2-(2-Bromoethoxy)anisole Chemical Properties

Melting point:

43-45 °C(Solv: ethanol (64-17-5))

Boiling point:

135-140 °C(Press: 7 Torr)

Density 

1.382±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

color 

Pale Beige

CAS DataBase Reference

4463-59-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-52/53

Safety Statements 

22-61

HazardClass 

IRRITANT

2-(2-Bromoethoxy)anisole Usage And Synthesis

Uses

2-(2-Bromoethoxy)anisole can be used as HIV inhibitors.

Synthesis

GENERAL METHOD: 1,2-Dibromoethane (0.02 mol) was dissolved in 40 mL of acetone and added slowly and dropwise to a 30 mL solution of acetone containing guaiacol (0.08 mol) and K2CO3 (0.04 mol). Subsequently, a catalytic amount of KI (0.3 mmol) was added and the reaction mixture was stirred at 60 °C for 24-72 hours. Upon completion of the reaction, the inorganic residue was removed by filtration and the organic phase was concentrated under vacuum. The crude product was purified by silica gel column chromatography using ethyl acetate/hexane mixed solvent as elution system.

References

[1] Farmaco, Edizione Scientifica, 1986, vol. 41, # 10, p. 794 - 800
[2] Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1997, p. 449 - 462
[3] European Journal of Medicinal Chemistry, 2009, vol. 44, # 2, p. 809 - 817
[4] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 6, p. 527 - 531
[5] European Journal of Medicinal Chemistry, 2016, vol. 108, p. 334 - 346

2-(2-Bromoethoxy)anisole(4463-59-6)Related Product Information

• Bromoethane
• Butylated hydroxyanisole
• p-Anisidine
• o-Anisaldehyde
• Decabromodiphenyl oxide
• 3-(METHOXYMETHOXY)BENZALDEHYDE
• p-Anisaldehyde
• Tetrabromobisphenol A bis(dibromopropyl ether)
• m-Anisyl alcohol
• 4-Methoxyphenylacetic acid
• Ethoxyquin
• Anisole
• (3-Methoxyphenyl)acetonitrile
• (Trifluoromethoxy)benzene
• 2-(2-Ethoxyphenoxy)ethyl bromide
• 2-(2-Ethoxyphenoxy)ethyl Methanesulfonate
• Tamsulosin
• (R)-2-(4-Methoxyphenyl)-1-methylethanamine