1-Methyl-2-undecyl-1,4-dihydroquinoline-4-one Chemical Properties

Boiling point:

419.9±45.0 °C(Predicted)

Density 

0.975±0.06 g/cm3(Predicted)

pka

2.52±0.70(Predicted)

1-Methyl-2-undecyl-1,4-dihydroquinoline-4-one Usage And Synthesis

Uses

1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of MAO-B activity with the IC50 and Ki values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS[1][2].

IC 50

MAO-B: 15.3 μM (IC₅₀); MAO-B: 9.91 μM (Ki)

References

[1] Toshiya K, et al. Isolation and Structure Elucidation of Three Quinolone
[2] Lee MK, et al. 1-methyl-2-undecyl-4(1H)-quinolone as an irreversible and selective inhibitor of type B monoamine oxidase. Chem Pharm Bull (Tokyo). 2003;51(4):409-411. DOI:10.1248/cpb.51.409

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