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ChemicalBook >  Product Catalog >  Biochemical Engineering >  Condensing agent >  (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate

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(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Basic information

Product Name:
(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate
Synonyms:
  • (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1- pyrrolidinylphosphonium hexafluorophosphate(PyAOP)
  • ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphoniuM hexafluorophosphate(V)
  • PyAOP (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1- pyrrolidinylphosphoniuM hexafluorophosphate
  • (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinyl-phosphorus hexafluorophosphate
  • tris(pyrrolidin-1-yl)({3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy})phosphanium
  • (7Azabenzotriazol1yloxy)tripyrrolidinophosphonium hexafluophosphate
  • (7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphonium hexafluoropho sphate, 99+% white crystalline powder
  • ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexa
CAS:
156311-83-0
MF:
C17H27F6N7OP2
MW:
521.39
EINECS:
627-192-4
Product Categories:
  • Coupling Reagent
Mol File:
156311-83-0.mol
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(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Chemical Properties

Melting point:
163-168 °C(lit.)
RTECS 
TH3890000
storage temp. 
-20°C
solubility 
Soluble in water or 1% acetic acid
form 
Powder or Crystalline Powder
color 
White to off-white
Water Solubility 
Soluble in water.
InChIKey
CBZAHNDHLWAZQC-UHFFFAOYSA-N
CAS DataBase Reference
156311-83-0(CAS DataBase Reference)
EPA Substance Registry System
Phosphorus(1+), [3-(hydroxy-.kappa.O)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1) (156311-83-0)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29339900
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(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Usage And Synthesis

Chemical Properties

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate is white to off-white crystalline powder

Uses

PyAOP is a phosphonium salt used as a coupling reagent in solid-phase peptide synthesis, without undergoing side reactions with the amino terminus. PyAOP is a derivative of HOAt (H805070).

Uses

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate is used as a coupling reagent in solid phase peptide synthesis. It is preferred over HATU, because it does not side react at the N-terminus of the peptide. Compared to the HOBt derivates, PyAOP (and HOAt in general) are more reactive due to the additional nitrogen.

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