(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Chemical Properties

Melting point:

163-168 °C(lit.)

RTECS 

TH3890000

storage temp. 

-20°C

solubility 

Soluble in water or 1% acetic acid

form 

Powder or Crystalline Powder

color 

White to off-white

Water Solubility 

Soluble in water.

InChI

InChI=1S/C17H27N7OP.F6P/c1-2-11-21(10-1)26(22-12-3-4-13-22,23-14-5-6-15-23)25-24-17-16(19-20-24)8-7-9-18-17;1-7(2,3,4,5)6/h7-9H,1-6,10-15H2;/q+1;-1

InChIKey

CBZAHNDHLWAZQC-UHFFFAOYSA-N

SMILES

[P+5]([F-])([F-])([F-])([F-])([F-])[F-].[P+](N1CCCC1)(N1CCCC1)(N1CCCC1)ON1N=NC2C=CC=NC1=2

CAS DataBase Reference

156311-83-0(CAS DataBase Reference)

EPA Substance Registry System

Phosphorus(1+), [3-(hydroxy-.kappa.O)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1) (156311-83-0)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29339900

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Usage And Synthesis

Chemical Properties

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate is white to off-white crystalline powder

Uses

PyAOP is a phosphonium salt used as a coupling reagent in solid-phase peptide synthesis, without undergoing side reactions with the amino terminus. PyAOP is a derivative of HOAt (H805070).

Uses

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate is used as a coupling reagent in solid phase peptide synthesis. It is preferred over HATU, because it does not side react at the N-terminus of the peptide. Compared to the HOBt derivates, PyAOP (and HOAt in general) are more reactive due to the additional nitrogen.

reaction suitability

reaction type: Coupling Reactions

(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate(156311-83-0)Related Product Information

• 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate
• CHLOROPHOSPHONAZO III
• Polyvinylpyrrolidone
• N-Methyl-2-pyrrolidone
• Lithium hexafluorophosphate
• METHYL-2-PYRROLIDONE
• TRIS(DIETHYLAMINO)PHOSPHINE
• 7-Azabenzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate
• HOAt
• Hexafluorophosphoric acid
• PVP-VACOPOLYMERSERIES
• 1H-1,2,3-TRIAZOLO[4,5-B]PYRIDINE
• (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate