DIHYDROERGOTAMINE MESYLATE
DIHYDROERGOTAMINE MESYLATE Basic information
- Product Name:
- DIHYDROERGOTAMINE MESYLATE
- Synonyms:
-
- 5'-Benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxo-9,10-dihydroergotaman
- 9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trionemonomethanesulfonate
- 9,10-dihydroergotaminemesylate
- 9,10-dihydro-ergotaminmonomethanesulfonate(salt)
- Agit
- Angionorm
- D.H.E. 45
- Dergotamine
- CAS:
- 6190-39-2
- MF:
- C34H41N5O8S
- MW:
- 679.78
- EINECS:
- 228-235-6
- Product Categories:
-
- MIGRANAL
- Aromatics
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Organics
- Ergot Alkaloids
- Neurobiology
- Pharmacologicals
- Adrenoceptor
- Mol File:
- 6190-39-2.mol
DIHYDROERGOTAMINE MESYLATE Chemical Properties
- Melting point:
- 232°C
- refractive index
- -20 ° (C=0.25, JP Method)
- storage temp.
- Store at RT
- solubility
- methanol: 21 mg/mL
- form
- powder
- color
- white
- Merck
- 14,3174
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
- CAS DataBase Reference
- 6190-39-2(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
DIHYDROERGOTAMINE MESYLATE Usage And Synthesis
Description
Dihydroergotamine mesylate (6190-39-2) is a full agonist at serotonin 5HT1B and 5HT1D receptors, IC50= 2 and 2.2 nM respectively1 and also at 5HT1A and 5HT1F receptors2. One of the oldest agents for treatment of migraine.3 Also acts as a potent vasoconstrictor and alpha-adrenergic antagonist.4
Chemical Properties
White to Off-White Solid
Uses
α-Androgenic blocker with selective venoconstrictor properties. Also binds to serotonin 5HT1-receptors. Antimigraine.
Uses
vasoconstrictor, antimigraine
Uses
Agonist at vascular serotonin receptors; partial agonist at alpha-adrenergic and dopamine D2 receptors
Definition
ChEBI: The methanesulfonic acid salt of dihydroergotamine, a semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine. Both the mesylate and the tartrate salts are used for the treatment of migraine and orthostatic hypotens on.
brand name
D.H.E. 45 (Valeant); Migranal (Valeant) .
Biological Activity
Partial α -adrenergic agonist. Partial D 2 dopaminergic receptor agonist. Competitive 5-HT antagonist.
storage
Room temperature
References
Lesage et al. (1998), Agnostic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines; J. Pharmacol., 123 1655 Silberstein (1997), The pharmacology of ergotamine and dihydroergotamine; Headache, 37 Suppl 1 S15 Silberstein and McCrory (2003), Ergotamine and dihydroergotamine: history, pharmacology, and efficacy; Headache, 43 144 Lipton (1997), Ergotamine tartrate and dihydroergotamine mesylate: safety profiles; Headache, 37 Suppl.1 S33
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