Tri(Ethylene Glycol) DI-P-Toluenesulfonate Chemical Properties

Melting point:

78-82 °C(lit.)

Boiling point:

534.03°C (rough estimate)

Density 

1.3164 (rough estimate)

refractive index 

1.6000 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in ethanol.

form 

powder to crystal

color 

White to Almost white

BRN 

632509

InChI

InChI=1S/C20H26O8S2/c1-17-3-7-19(8-4-17)29(21,22)27-15-13-25-11-12-26-14-16-28-30(23,24)20-9-5-18(2)6-10-20/h3-10H,11-16H2,1-2H3

InChIKey

KCONMNWPRXAWKK-UHFFFAOYSA-N

SMILES

C(OCCOS(C1=CC=C(C)C=C1)(=O)=O)COCCOS(C1=CC=C(C)C=C1)(=O)=O

CAS DataBase Reference

19249-03-7(CAS DataBase Reference)

EPA Substance Registry System

Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-, bis(4-methylbenzenesulfonate) (19249-03-7)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29093090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Tri(Ethylene Glycol) DI-P-Toluenesulfonate Usage And Synthesis

Description

Tos-PEG4-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Chemical Properties

WHITE POWDER

Uses

Tri(ethylene glycol) di-p-toluenesulfonate is used in the synthesis of 1-[4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl] ethanone.

Synthesis

2,2'-[1,2-ethanediylbis(oxy)]bisethanol and p-toluenesulfonyl chloride can be used as raw materials for the synthesis of Tri(Ethylene Glycol) DI-P-Toluenesulfonate.

References

[1] Organic and Biomolecular Chemistry, 2006, vol. 4, # 11, p. 2082 - 2087
[2] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 14, p. 4841 - 4856
[3] Organic and Biomolecular Chemistry, 2015, vol. 13, # 30, p. 8335 - 8348
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 17, p. 7840 - 7855
[5] Journal of Organic Chemistry, 1992, vol. 57, # 24, p. 6678 - 6680

Tri(Ethylene Glycol) DI-P-Toluenesulfonate(19249-03-7)Related Product Information

• 2,2-Dimethyl-1,3-propanediol
• Triethylene glycol dimethacrylate
• Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate)
• ALLYL ISOVALERATE
• Magnesium Bisglycinate
• 4-FLUORO-3'-IODODIPHENYL ETHER
• 5-NITRO-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER
• 1-CBZ-2-PIPERIDINECARBOXYLIC ACID
• Risedronic acid
• Benzonitrile, 3-bromo-2-fluoro- (9CI)
• Tos-PEG3-t-butyl ester
• TETRAETHYLENE GLYCOL DI-P-TOSYLATE
• TOS-PEG5-THP
• Tos-PEG7-t-butyl ester
• Tos-PEG9-t-butyl ester
• Tos-PEG5-CH2CO2t-butyl ester
• Tos-PEG13-t-butyl ester
• Tos-PEG3-CH2CO2tBu