IDOXIFENE
IDOXIFENE Basic information
- Product Name:
- IDOXIFENE
- Synonyms:
-
- IDOXIFENE
- (e)-1-(2-(4-(1-(4-iodophenyl)-2-phenyl-1-butenyl)phenoxy)ethyl)pyrrolidine
- (e)-pyrrolidin
- cb7432
- iodoxifene
- pyrrolidino-4-iodotamoxifen
- (E)-1-[4-(2-(Pyrrolidin-1-yl)ethoxy)phenyl]-1-(4-iodophenyl)-2-phenyl-1-butene
- 1-[2-[4-[(1E)-1-(4-Iodophenyl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]pyrrolidine
- CAS:
- 116057-75-1
- MF:
- C28H30INO
- MW:
- 523.45
- Mol File:
- 116057-75-1.mol
IDOXIFENE Chemical Properties
- Melting point:
- 108-109° (McCague et al.)
- Boiling point:
- 573.4±50.0 °C(Predicted)
- Density
- 1.329
- storage temp.
- 2-8°C
- pka
- 9.61±0.20(Predicted)
- form
- Solid
- color
- White to off-white
IDOXIFENE Usage And Synthesis
Uses
SERM for treatment of urogenital atrophy weak estrogen and antiestrogen in uterus
Uses
Idoxifene is a non-steroidal estrogen antagonist. It is structurally analogous to tamoxifen (T006000).
Definition
ChEBI: Idoxifene is a stilbenoid.
in vivo
Animals receive daily intraperitoneal injections of Estradiol (0.5 mg/kg) and an oral gavage of Idoxifene (0.02, 0.1, and 0.5 mg/kg) for 3 days after Dimethylnitrosamine (DMN) treatment. The blood levels of LDH and Estradiol (E2) and histological grades (scores 0 to 5) of liver zone 3 necrosis are evaluated. Idoxifene at doses of over 0.1 mg/kg significantly reduces the hepatic levels of collagen and MDA in the DMN model in a dose-dependent manner. Although Idoxifene and E2 are administered by different routes, i.e., by oral ingestion and intraperitoneal injection, respectively, the antifibrotic effect of a dose of 0.5 mg/kg of Idoxifene is somewhat greater than that of the same dose of E2[2].
IDOXIFENESupplier
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