Benserazide hydrochloride Chemical Properties

Melting point:

146°C

storage temp. 

2-8°C

solubility 

H₂O: 10 mg/mL

form 

solid

color 

White to Off-White

PH

pH(10g/L, 25℃) : 4.0～5.0

biological source

synthetic

Water Solubility 

Soluble in water, dimethyl sulfoxide and methanol. Insoluble in ethanol and acetone.

Sensitive 

Light Sensitive

λmax

272nm(HCl aq.)(lit.)

Merck 

14,1050

InChI

InChI=1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H

InChIKey

ULFCBIUXQQYDEI-UHFFFAOYSA-N

SMILES

C(NNCC1=CC=C(O)C(O)=C1O)(=O)C(CO)N.[H]Cl

CAS DataBase Reference

14919-77-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

2

RTECS 

VT9632300

HS Code 

29280000

MSDS

• Language:English Provider:SigmaAldrich

Benserazide hydrochloride Usage And Synthesis

Description

Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity. It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.

Chemical Properties

White Crystalline Solid

Uses

Used as antiparkinsonian. A peripheral decarboxylase inhibitor

Uses

Antiparkinsonian;DOPA decarboxylase inhibitor

Uses

Inhibitor of L-aromatic amino acid decarboxylaseBenserazide hydrochloride is used as an antiparkinsonian. It is a peripheral decarboxylase inhibitor. It is used as an inhibitor for aromatic L-aminoacid decarboxylase. Further, it serves as an inhibitor of tyrosine hydroxylase (TH) and Tryptophan hydroxylase (TPH) inhibitor.

Definition

ChEBI: A hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of park nsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide hydrochloride has no antiparkinson actions whe given alone.

General Description

Benserazide is a peripheral decarboxylase inhibitor.

Biochem/physiol Actions

Inhibitor of L-aromatic amino acid decarboxylase.

References

[1] SCHULTZ E. L-dopa as Substrate for human duodenal catechol-O-methyltransferase and aromatic L-amino acid decarboxylase[J]. Biomedical Chromatography, 1990, 4 6: 242-244. DOI: 10.1002/bmc.1130040607
[2] BENDER D A. Inhibition in vitro of the enzymes of the oxidative pathway of tryptophan metabolism and of nicotinamide nucleotide synthesis by benserazide, carbidopa and isoniazid[J]. Biochemical pharmacology, 1980, 29 5: Pages 707-712. DOI: 10.1016/0006-2952(80)90544-4
[3] WEI LI. Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2.[J]. ACS Chemical Biology, 2017: 58. DOI: 10.1186/s13046-017-0530-4
[4] HUO SHEN . Effects of benserazide on l-DOPA-derived extracellular dopamine levels and aromatic l-amino acid decarboxylase activity in the striatum of 6-hydroxydopamine-lesioned rats[J]. International congress series, 2003, 1251: Pages 199-204. DOI: 10.1016/s0531-5131(03)00119-5

Benserazide hydrochloride(14919-77-8)Related Product Information

• 1-AdaMantanethylaMine
• Buflomedil hydrochloride
• Entacapone
• Donepezil Hydrochloride
• Topotecan hydrochloride
• Rimantadine hydrochloride
• Pirenzepine hydrochloride
• 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride
• FLUOXETINE HYDROCHLORIDE
• Robenidine hydrochloride
• 1-beta-D-Arabinofuranosylcytosine hydrochloride
• Clorprenaline hydrochloride
• Moroxydine hydrochloride
• Flunarizine dihydrochloride
• Methyl nicotinoylacetate
• Hydrazine monohydrochloride
• Bromhexine hydrochloride
• Dexmedetomidine hydrochloride