(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Chemical Properties

Melting point:

148-152 °C(lit.)

Boiling point:

508.0±50.0 °C(Predicted)

Density 

1.125±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >6.0 mg/mL

form 

solid

pka

13.88±0.20(Predicted)

color 

pale yellow

optical activity

[α]25/D +16°, c = 1 in 1 M HCl

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE Usage And Synthesis

Description

(+)-Atenolol is an enantiomer of the β₁-adrenergic receptor (β₁-AR) antagonist (±)-atenolol . (+)-Atenolol inhibits radioligand binding to β-ARs on sarcolemma-enriched membranes (K_i = 8.61 μM). Unlike (–)-atenolol and (±)-antenolol, (+)-atenolol has no effect on blood pressure in spontaneously hypertensive rats.

Uses

Cardioselective β-adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic (class II).

Uses

Antihypertensor

Uses

less active enantiomer

Definition

ChEBI: The (R)-enantiomer of atenolol.

References

[1] stoschitzky k, egginger g, zernig g, et al. stereoselective features of (r)- and (s)-atenolol: clinical pharmacological, pharmacokinetic, and radioligand binding studies[j]. chirality, 1993, 5(1): 15-19.

(+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE(56715-13-0)Related Product Information

• S(-)-ATENOLOL
• (+)-4-[2-HYDROXY-3-[(1-METHYLETHYL)-AMINO]PROPOXY]BENZENEACETAMIDE
• Atenolol
• 4-Hydroxyphenylacetamide
• 4-METHOXYPHENYLACETAMIDE
• 1-AMINO-3-PHENOXY-PROPAN-2-OL
• 3-(4-methylphenoxy)propan-1-amine
• CHEMBRDG-BB 5482082
• (2R)-(+)-1-AMINO-3-PHENOXY-2-PROPANOL
• AKOS BC-1949
• 4-(3-Amino-2-hydroxypropoxy)phenylacetamide
• 3-(ISOPROPYLAMINO)-1,2-PROPANEDIOL
• 1-AMINO-3-(4-ETHYLPHENOXY)PROPAN-2-OL
• (R)-3-ISOPROPYLAMINO-1,2-PROPANEDIOL
• 1-METHYLAMINO-3-PHENOXY-PROPAN-2-OL
• CHEMBRDG-BB 9070877
• ATENOLOL IMPURITY STANDARD