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RUBUSOSIDE

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RUBUSOSIDE Basic information

Product Name:
RUBUSOSIDE
Synonyms:
  • RUBUSOSIDE
  • (4α)-13-(β-D-glucopyranosyloxy)kaur-16-en-18-oic acid β-D-glucopyranosyl ester
  • Rubusoside (100 mg)
  • 13β-(β-D-Glucopyranosyloxy)kaur-16-en-18-oic acid β-D-glucopyranosyl ester
  • RUBESCENSIN A(RG)
  • (4alpha)-13-(beta-D-Glucopyranosyloxy)kaur-16-en-18-oic acid beta-D-glucopyranosyl ester
  • Rubus Suavissmus S. Lee
  • Rubusoside(P)
CAS:
64849-39-4
MF:
C32H50O13
MW:
642.73
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
64849-39-4.mol
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RUBUSOSIDE Chemical Properties

Melting point:
178～181℃
Boiling point:
802.5±65.0 °C(Predicted)
Density 
1.45
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
form 
Solid
pka
12.51±0.70(Predicted)
color 
White to Off-White
optical activity
[α]/D -37 to -47°, c =0.5 in methanol
Stability:
Hygroscopic
InChIKey
YWPVROCHNBYFTP-OSHKXICASA-N
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Safety Information

WGK Germany 
3
HS Code 
29389090
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RUBUSOSIDE Usage And Synthesis

Chemical Properties

White crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from sweet tea.

Uses

Rubusoside is used as a nutritive sweetener, derived from .Stevia rebaudiana Stevia glycosiede.

Definition

ChEBI: Rubusoside is a steviol glycoside that is steviol in which both the carboxy group and the tertiary allylic hydroxy group have been converted to their corresponding beta-D-glucosides. A precious bioactive natural sweetener which mainly exists the in Chinese sweet tea plant, Rubus suavissimus. It has a role as a sweetening agent and a plant metabolite. It is a beta-D-glucoside, a tetracyclic diterpenoid, a bridged compound and a steviol glycoside. It is functionally related to a steviol.

Biological Activity

Rubusoside is a natural next generation sugar substitute isolated from Rubus suavissimus S. Lee. Rubusoside exhibits antiangiogenic and antiallergic properties. It can be used as a solubilizing agent for assorted biologically active agents.

in vivo

Rubusoside (50-300 mg/kg; po; single dose) exerts anti-inflammatory and antiasthmatic activities in an OVA-induced experimental allergic asthma mouse model. Moreover, Rubusoside inhibits OVA-induced activation of the NF-κB pathway in lung tissue[4].

Animal Model:Ovalbumin‐induced mice allergic asthma model[4]
Dosage:50, 150, 300 mg/kg
Administration:po; mixed with PBS (phosphate-buffered saline, pH 7.4) 1 hr before OVA treatment (intraperitoneal injected with 20 μg OVA and intranasal spray 1% OVA solution from Day 21 to Day 23)
Result:Contributed to the decrease of inflammatory cytokines (TNF-α, IL-13, IL-6, IL-5, and IL-4) inside the BALF of mice with asthma.
Led a decline of OVA-dependent IgE and IgG1 inside the serum was also noticed in these mice.
Enhanced the mRNA level of Foxp3 inside the mice lung affected with asthma while decrease that of IL-17A, IL-23, and RORγt.

RUBUSOSIDESupplier

Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Email
sj_scrc@sinopharm.com
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Email
y.liu@mail.biobiopha.com
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Email
cwb1@biopurify.cn
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Email
climaxbiotech@gmail.com
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