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CORTISOL-9,11,12,12-D4

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CORTISOL-9,11,12,12-D4 Basic information

Product Name:
CORTISOL-9,11,12,12-D4
Synonyms:
  • 17-Hydroxycorticosterone-9,11,12,12-d4, Cortisol-9,11,12,12-d4, Hydrocortisone-9,11,12,12-d4, Kendall's compound F (9,11,12,12-d4), Reichstein's substance M (9,11,12,12-d4), 4-Pregnene-11β,17α,21-triol-3,20-dione-d4 (9,11,12,12-d4), 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione-d4 (9,11,12,12-d4)
  • CORTISOL-9,11,12,12-D4
  • HYDROCORTISONE (9,11,12,12-D4)
  • Cortisol-D4 (9,11,12,12-D4)
  • (11β)-11,17,21-Trihydroxy-pregn-4-ene-3,20-dione-d4
  • 11β-Hydroxycortisone-d4
  • 17-Hydroxycorticosterone-d4
  • Acticort-d4
CAS:
73565-87-4
MF:
C21H26D4O4
MW:
350.49
EINECS:
694-327-1
Product Categories:
  • Steroids & Hormones - 13C & 2H
  • Intermediates & Fine Chemicals
  • Isotope Labelled Compounds
  • Pharmaceuticals
  • Steroids
Mol File:
73565-87-4.mol
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CORTISOL-9,11,12,12-D4 Chemical Properties

Melting point:
211-214 °C
Flash point:
9℃
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly, Heated), Water
form 
Solid
color 
White to Off-White
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Safety Information

Hazard Codes 
Xn,T,F
Risk Statements 
63-39/23/24/25-23/24/25-11
Safety Statements 
36/37-45-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
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CORTISOL-9,11,12,12-D4 Usage And Synthesis

Description

Hydrocortisone-d4 is intended for use as an internal standard for the quantification of hydrocortisone/cortisol by GC- or LC-MS. Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH). It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR), with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response. Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson''s disease.

Chemical Properties

White Solid

Uses

Labelled Cortisol (H714615). Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.

Uses

Anti-inflammatory hormone

General Description

Cortisol, also known as hydrocortisone, is a glucocorticoid produced by the adrenal gland. This stable labeled internal standard is suitable for quantitation of cortisol levels in whole blood by LC-MS/MS for newborn screening of congenital adrenal hyperplasia (CAH) and in serum or plasma by LC-MS/MS for determination of several diseases including Cushing′s syndrome, Addison′s disease, and Sheehan′s syndrome.

CORTISOL-9,11,12,12-D4Supplier

J & K SCIENTIFIC LTD.
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Chemsky(shanghai)International Co.,Ltd.
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Clearsynth Labs Limited
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