2,4'-Dibromoacetophenone
2,4'-Dibromoacetophenone Basic information
- Product Name:
- 2,4'-Dibromoacetophenone
- Synonyms:
-
- P-BROMOPHENACYL BROMIDE
- PBPB
- OMEGA-BROMOACETOPHENONE
- bromomethyl4-bromophenylketone
- bromomethylp-bromophenylketone
- omega,4-dibromoacetophenone
- p,alpha-dibromoacetophenone
- p-bromophenacyl-8
- CAS:
- 99-73-0
- MF:
- C8H6Br2O
- MW:
- 277.94
- EINECS:
- 202-783-6
- Product Categories:
-
- Other enzyme inhibitors and activators
- Aromatic Acetophenones & Derivatives (substituted)
- Carboxyl Group Labeling Reagents for HPLC
- UV Detection (HPLC Labeling Reagents)
- Analytical Chemistry
- HPLC Labeling Reagents
- Adehydes, Acetals & Ketones
- Bromine Compounds
- Analytical Reagents
- Analytical/Chromatography
- Bioactive Small Molecules
- Biochemicals and Reagents
- Building Blocks
- C7 to C8
- Carbonyl Compounds
- Cell Biology
- Chemical Synthesis
- D-DIF
- Derivatization agents
- Derivatization Reagents
- Derivatization Reagents HPLC
- Fluorescence
- Halogenated
- Ketones
- Luminescent Compounds/Detection
- Organic Building Blocks
- Mol File:
- 99-73-0.mol
2,4'-Dibromoacetophenone Chemical Properties
- Melting point:
- 108-110 °C(lit.)
- Boiling point:
- 1415°C/760mm
- Density
- 1.7855 (rough estimate)
- refractive index
- 1.5560 (estimate)
- storage temp.
- Store below +30°C.
- solubility
- DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): insol
- form
- Crystalline Solid
- color
- Slightly yellow to beige
- Water Solubility
- Soluble in dimethyl sulfoxide (5 mg/ml), methanol (20 mg/ml), toluene and ethanol. Insoluble in water.
- Sensitive
- Lachrymatory
- Merck
- 14,1427
- BRN
- 607604
- Stability:
- Stable. Incompatible with strong bases, strong reducing agents, strong oxidizing agents.
- InChIKey
- FKJSFKCZZIXQIP-UHFFFAOYSA-N
- CAS DataBase Reference
- 99-73-0(CAS DataBase Reference)
- EPA Substance Registry System
- Ethanone, 2-bromo-1-(4-bromophenyl)- (99-73-0)
Safety Information
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 2
- RTECS
- AM6950000
- F
- 19-21
- Hazard Note
- Corrosive/Lachrymatory
- TSCA
- T
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29147090
MSDS
- Language:English Provider:2,4'-Dibromoacetophenone
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
2,4'-Dibromoacetophenone Usage And Synthesis
Chemical Properties
2,4'-Dibromoacetophenone is off-white crystals or powder
Uses
Identification of carboxylic acids.
Uses
Undergoes condensation reactions with aldehydes in the presence of SnCl21 or SmI32 to afford α,β-unsaturated ketones. Also useful in the esterification of carboxylic acids.3
Uses
2,4'-Dibromoacetophenone is used as a reagent for analysis of fatty acids by HPLC as 4-bromophenacyl esters, for use in the protection of phenols and carboxylic acids. It undergoes condensation reactions with aldehydes in the presence of SnCl2 or SmI3 to afford α,β-unsaturated ketones. It is also useful in the esterification of carboxylic acids.
General Description
A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 0.5 μM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM.
Biochem/physiol Actions
Cell permeable: yes
Purification Methods
Crystallise the bromide from EtOH (ca 8mL/g). [Beilstein 7 IV 652.]
2,4'-Dibromoacetophenone Preparation Products And Raw materials
Preparation Products
Raw materials
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2,4'-Dibromoacetophenone(99-73-0)Related Product Information
- 3-Nitroacetophenone
- 4-Bromophenethyl alcohol
- Bromoacetyl bromide
- 4-Nitroacetophenone
- 4-Bromoanisole
- L-PICEIN
- Ethidium bromide
- Clidinium bromide
- 4'-Methoxyacetophenone
- Sodium bromate
- Acetophenone
- 4-Bromobenzotrifluoride
- 4-Bromotoluene
- 4-Bromobenzaldehyde
- 2',4'-Difluoroacetophenone
- 1,4-Dibromobenzene
- Acetyl bromide
- 3-Aminoacetophenone