TRIFLUOROACETIC ACID HYDRAZIDE Chemical Properties

Melting point:

111 °C

Boiling point:

84-86 °C(Press: 14 Torr)

Density 

1.462±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

form 

solid

pka

9.47±0.20(Predicted)

color 

White

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

2916199590

TRIFLUOROACETIC ACID HYDRAZIDE Usage And Synthesis

Uses

Trifluoroacetic acid hydrazide is used in chemical synthesis applications. It is used in the preparation of sitagliptin intermediates, pyridazinone derivatives and fluoronitrocarboxylic acid hydrazides, among other organic compounds.

Synthesis

Step 2 Preparation of trifluoroacetohydrazide: Ethyl trifluoroacetate (14.2 g, 0.10 mol) and hydrazine hydrate (5.54 g, 0.11 mol) were dissolved in ethanol (25 mL), and heated and refluxed for 6 hours. After the reaction was completed, the solvent was removed by distillation under reduced pressure, and the resulting residue was dried under vacuum to obtain trifluoroacetohydrazide (12.3 g, 96% yield), the product was a transparent oil, which was solidified after standing.

References

[1] Patent: US6423713, 2002, B1
[2] Patent: US6514977, 2003, B1
[3] Patent: US6979686, 2005, B1. Location in patent: Page/Page column 134
[4] Magnetic Resonance in Chemistry, 1990, vol. 28, p. 331 - 336
[5] Journal of the Indian Chemical Society, 2010, vol. 87, # 5, p. 589 - 593

TRIFLUOROACETIC ACID HYDRAZIDE(1538-08-5)Related Product Information

• TRIFLUOROPYRUVIC ALDEHYDE
• TRIFLUOROACETIC ACID HYDRAZIDE
• Fluoroacetic acid
• Trifluoroacetic acid
• Hydrazine acetate
• N-TRIFLUOROACETYL-N'-(TRIFLUOROACETIMIDOYL)HYDRAZINE
• 2,2,2-TRIFLUORO-N'-(TRIFLUOROACETYL)ACETOHYDRAZIDE
• 1-TRIFLUOROACETYL-4-THIOSEMICARBAZIDE
• TOSLAB 12889
• TOSLAB 14669
• HYDRAZINIUM N1-(2,2,2-TRIFLUOROACETYL)-2,2,2-TRIFLUOROETHANEHYDRAZONOATE
• N'-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-2,2,2-TRIFLUOROACETOHYDRAZIDE
• TOSLAB 13502
• AURORA 1721
• SALOR-INT L354120-1EA
• 3-(4-CHLOROPHENYL)-6-(4-HYDROXY-3,5-DIMETHYLPHENYL)-1-(TRIFLUOROACETYL)-1,6-DIHYDRO-1,2,4-TRIAZIN-5(2H)-ONE
• 2,2,2-TRIFLUORO-N'-(6-FLUORO-2-PYRIDINYL)ACETOHYDRAZIDE
• 4-METHYL-1-(TRIFLUOROACETYL)-3-THIOSEMICARBAZIDE