ANTIBIOTIC UCN-02 Chemical Properties

Boiling point:

705.7±60.0 °C(Predicted)

Density 

1.63±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

solution in ethanol.

pka

12.25±0.70(Predicted)

ANTIBIOTIC UCN-02 Usage And Synthesis

Description

UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01 first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. UCN-02 inhibits protein kinase C with a slightly reduced potency than UCN-01 (IC₅₀ = 62 and 4.1 nM, for UNC-02 and UCN-01, respectively) and is cytotoxic to the growth of HeLa S3 cells.

Uses

UCN-02 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms.

Uses

UCN-02 is an antibiotic and an indolocarbazole isolated from a high staurosporine-producing?Streptomyces?culture. Related analogs of staurosporine which is non-specific protein kinase inhibitor.

References

[1] takahashi, i. ,saitoh, y.,yoshida, m., et al. ucn-01 and ucn-02, new selective inhibitors of protein kinase c. ii. purification, physico-chemical properties, structural determination and biological activities. j.antibiot.(tokyo) 42(4), 571-576 (1989).
[2] newton a c. protein kinase c: structure, function, and regulation[j]. journal of biological chemistry, 1995, 270(48): 28495-28498.

ANTIBIOTIC UCN-02(121569-61-7)Related Product Information

• UCF-101
• 9-ISOPROPYLCARBAZOLE
• 1-(1-METHYL-1H-INDOL-4-YL)METHYLAMINE 97
• INDOLE-4-METHANOL
• 4-AMINOMETHYLINDOLE
• N-Ethyl-3-carbazolecarboxaldehyde
• Indole-4-carboxaldehyde
• K-252C
• (1-METHYL-1H-INDOL-4-YL)METHANOL
• (1-Methyl-1H-indol-5-yl)methanol
• C-(9-ETHYL-9H-CARBAZOL-3-YL)-METHYLAMINE
• 1-ethyl-1H-indole-5-carbaldehyde
• ANTIBIOTIC UCN-02
• 1H-INDOLE-5-CARBOXAMIDE, 97%
• (1-METHYL-1H-INDOL-5-YL)METHYLAMINE
• CARBAZOL-9-YL-METHANOL
• 11,12-Dihydroindolo[2,3-a]carbazole
• 1-METHYL-1H-INDOLE-4-CARBALDEHYDE