Basic information Safety Supplier Related

ANTIBIOTIC UCN-02

Basic information Safety Supplier Related

ANTIBIOTIC UCN-02 Basic information

Product Name:
ANTIBIOTIC UCN-02
Synonyms:
  • UCN-02
  • ANTIBIOTIC UCN-02
  • 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-, (3S,9S,10R,11R,13R)-
CAS:
121569-61-7
MF:
C28H26N4O4
MW:
482.53
Mol File:
121569-61-7.mol
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ANTIBIOTIC UCN-02 Chemical Properties

Boiling point:
705.7±60.0 °C(Predicted)
Density 
1.63±0.1 g/cm3(Predicted)
pka
12.25±0.70(Predicted)
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ANTIBIOTIC UCN-02 Usage And Synthesis

Description

UCN-02 is a derivative of staurosporine (Item No. 81590) and a stereoisomer of UCN-01 (Item No. 18130) first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. UCN-02 inhibits protein kinase C with a slightly reduced potency than UCN-01 (IC50 = 62 and 4.1 nM, for UNC-02 and UCN-01, respectively) and is cytotoxic to the growth of HeLa S3 cells.

Uses

UCN-02 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms.

Uses

UCN-02 is an antibiotic and an indolocarbazole isolated from a high staurosporine-producing?Streptomyces?culture. Related analogs of staurosporine which is non-specific protein kinase inhibitor.

ANTIBIOTIC UCN-02Supplier

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