TEMAFLOXACIN Chemical Properties

Melting point:

>200°C (dec.)

Boiling point:

608.9±55.0 °C(Predicted)

Density 

1.3372 (estimate)

storage temp. 

2-8°C(protect from light)

solubility 

Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

6.02±0.41(Predicted)

color 

White to Off-White

Stability:

Hygroscopic

TEMAFLOXACIN Usage And Synthesis

Description

Temafloxacin is a fluoroquinolone antibiotic that acts as a DNA topoisomerase inhibitor. It has broad antimicrobial activity against gram-positive and gram-negative bacteria, such as S. pneumoniae, M. hominis, and anaerobic bacteria, including B. fragilis.

Uses

Antibacterial (microbial DNA topoisomerase inhibitor).

Uses

Temafloxacin is an antimicrobial quinolone drug.

Definition

ChEBI: 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is a quinolone that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted at positions 1, 6, and 7 by 2,4-difluorophenyl, fluorine, and 3-methylpiperazin-1-yl groups, respectively. It is a quinolone, an amino acid, a monocarboxylic acid, an organofluorine compound, a secondary amino compound, a tertiary amino compound, a N-arylpiperazine and a quinolone antibiotic.

brand name

Omniflox (Abbott);8Omniflox 8Teflox 8Temac.

World Health Organization (WHO)

Temafloxacin, a quinolone antimicrobial, was introduced in 1991. Shortly afterwards, its use became associated with severe adverse effects, including hypoglycaemia, haemolytic anaemia, renal failure, hepatitis and anaphylactic reactions. This led to its worldwide withdrawal by the manufacturer.

TEMAFLOXACIN(108319-06-8)Related Product Information

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