2-Amino-4-phenylthiazole Chemical Properties

Melting point:

149-153 °C (lit.)

Boiling point:

363.4±11.0 °C(Predicted)

Density 

1.261±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 12 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml

pka

4.33±0.10(Predicted)

form 

Crystalline Solid

color 

White to yellow to pale orange

λmax

284nm(EtOH)(lit.)

BRN 

128609

InChIKey

PYSJLPAOBIGQPK-UHFFFAOYSA-N

CAS DataBase Reference

2010-06-2(CAS DataBase Reference)

NIST Chemistry Reference

2-Thiazolamine, 4-phenyl-(2010-06-2)

Safety Information

Hazard Codes 

Xn,Xi,T

Risk Statements 

22-37/38-41-25

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

RTECS 

XJ2878000

HazardClass 

IRRITANT

HazardClass 

6.1

PackingGroup 

III

HS Code 

29341000

Toxicity

mouse,LD50,intravenous,320mg/kg (320mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00815,

MSDS

• Language:English Provider:4-Phenylthiazol-2-amine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Amino-4-phenylthiazole Usage And Synthesis

Description

2-amino-4-phenyl Thiazole is a synthetic intermediate useful for pharmaceutical synthesis.

Uses

4-Phenyl-2-thiazolamine was used to prepare suberoylanilide hydroxamic acid (SAHA) analogs with cancer cell growth inhibitory activities. It was also used to synthesize ketone histone deacetylase inhibitors with antitumor activity in vivo.

2-Amino-4-phenylthiazole(2010-06-2)Related Product Information

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• ALTRENOGEST
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• 2-AMINO-4-(3,4-DIFLUOROPHENYL)THIAZOLE