DEFOSLIMOD
DEFOSLIMOD Basic information
- Product Name:
- DEFOSLIMOD
- Synonyms:
-
- DEFOSLIMOD
- α-D-Glucopyranose, 2-deoxy-6-O-[2-deoxy-2-[[(3R)-1-oxo-3-[(1-oxododecyl)oxy]tetradecyl]amino]-4-O-phosphono-β-D-glucopyranosyl]-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-, 1-(dihydrogen phosphate)
- CAS:
- 171092-39-0
- MF:
- C52H100N2O20P2
- MW:
- 1135.3
- Mol File:
- 171092-39-0.mol
More
Less
DEFOSLIMOD Chemical Properties
- Density
- 1.25±0.1 g/cm3(Predicted)
- pka
- 1.73±0.10(Predicted)
More
Less
DEFOSLIMOD Usage And Synthesis
Uses
Defoslimod (OM 174) is an agonist for TLR4 receptor and acts as an immunomodulator. Defoslimod activates macrophages and dendritic cells, induces cytokines secretion, and exhibits antitumor efficacy in rats[1].
References
[1] Isambert N, et al., Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors. BMC Cancer. 2013 Apr 2;13:172. DOI:10.1186/1471-2407-13-172