5-AMINO-3-PHENYLISOXAZOLE Chemical Properties

Melting point:

110-114 °C(lit.)

Boiling point:

379.3±30.0 °C(Predicted)

Density 

1.204±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

pka

-1.69±0.10(Predicted)

form 

Crystalline Powder

color 

Orange

CAS DataBase Reference

4369-55-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22

Safety Statements 

24/25

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich

5-AMINO-3-PHENYLISOXAZOLE Usage And Synthesis

Uses

3-Phenylon-5-aminoisoxazole is a heterocyclic organic compound that can be used as a pharmaceutical intermediate.

Chemical Properties

Yellow solid

Synthesis

GENERAL METHOD: Benzoylacetonitrile (100 mmol) was added to 15% aqueous sodium hydroxide solution (100 mL) followed by hydroxylamine (200 mmol). The reaction mixture was heated to reflux for 14 h. After cooling to room temperature, the resulting precipitate was separated by filtration and recrystallized with isopropanol.

References

[1] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 6, p. 1914 - 1925
[2] Organic Letters, 2017, vol. 19, # 4, p. 934 - 937
[3] Organic Letters, 2018, vol. 20, # 9, p. 2774 - 2777
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 3, p. 1082 - 1105
[5] Patent: EP1813606, 2007, A1. Location in patent: Page/Page column 81

5-AMINO-3-PHENYLISOXAZOLE(4369-55-5)Related Product Information

• 3-(4-CHLOROPHENYL)ISOXAZOL-5-AMINE
• 5-AMINO-3-PHENYLISOXAZOLE
• 3-(4-METHYLPHENYL)ISOXAZOL-5-AMINE
• 3-(2-FLUORO-PHENYL)-ISOXAZOL-5-YLAMINE
• 5-AMINO-3-(4-FLUOROPHENYL)ISOXAZOLE
• 3-(4-NITRO-PHENYL)-ISOXAZOL-5-YLAMINE
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• 5-AMINO-3-(4-METHOXYPHENYL)ISOXAZOLE
• 3-(4-METHOXYPHENYL)ISOXAZOL-5-AMINE
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• 3-(4-BROMOPHENYL)ISOXAZOL-5-AMINE
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• 5-ANILINO-3-PHENYL-4-ISOXAZOLECARBALDEHYDE
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• 1-Piperidineacetamide, N-(3-phenyl-5-isoxazolyl)-, monohydrochloride